tetano
Editor, Senior Moderator
AJNR Am J Neuroradiol
. 2020 Oct 22.
doi: 10.3174/ajnr.A6898. Online ahead of print.
Serial Imaging of Virus-Associated Necrotizing Disseminated Acute Leukoencephalopathy (VANDAL) in COVID-19
S Agarwal[SUP] 1 [/SUP], J Conway[SUP] 1 [/SUP], V Nguyen[SUP] 2 [/SUP], S Dogra[SUP] 2 [/SUP], P Krieger[SUP] 2 [/SUP], D Zagzag[SUP] 3 4 [/SUP], A Lewis[SUP] 1 4 [/SUP], K Melmed[SUP] 1 4 [/SUP], S Galetta[SUP] 1 [/SUP], R Jain[SUP] 5 4 [/SUP]
Affiliations
Abstract
Background and purpose: Various patterns of leukoencephalopathy have been described in coronavirus disease 2019 (COVID-19). In this article, we aimed to describe the clinical and imaging features of acute disseminated leukoencephalopathy in critically ill patients with COVID-19 and the imaging evolution during a short-term follow-up.
Materials and methods: We identified and reviewed the clinical data, laboratory results, imaging findings, and outcomes for 8 critically ill patients with COVID-19 with acute disseminated leukoencephalopathy.
Results: All patients demonstrated multiple areas of white matter changes in both cerebral hemispheres; 87.5% (7/8) of patients had a posterior predilection. Four patients (50%) had short-term follow-up imaging within a median of 17 days after the first MR imaging; they developed brain atrophy, and their white matter lesions evolved into necrotizing cystic cavitations. All (8/8) patients had inflammatory cytokine release syndrome as demonstrated by elevated interleukin-6, D-dimer, lactate dehydrogenase, erythrocyte sedimentation rate, C-reactive protein, and ferritin levels. Most (7/8; 87.5%) patients were on prolonged ventilator support (median, 44.5 days; interquartile range, 20.5 days). These patients had poor functional outcomes (6/8 [75%] patients were discharged with mRS 5) and high mortality (2/8, 25%).
Conclusions: Critically ill patients with COVID-19 can develop acute disseminated leukoencephalopathy that evolves into cystic degeneration of white matter lesions with brain atrophy during a short period, which we dubbed virus-associated necrotizing disseminated acute leukoencephalopathy. This may be the result of COVID-19-related endothelial injury, cytokine storm, or thrombotic microangiopathy.
. 2020 Oct 22.
doi: 10.3174/ajnr.A6898. Online ahead of print.
Serial Imaging of Virus-Associated Necrotizing Disseminated Acute Leukoencephalopathy (VANDAL) in COVID-19
S Agarwal[SUP] 1 [/SUP], J Conway[SUP] 1 [/SUP], V Nguyen[SUP] 2 [/SUP], S Dogra[SUP] 2 [/SUP], P Krieger[SUP] 2 [/SUP], D Zagzag[SUP] 3 4 [/SUP], A Lewis[SUP] 1 4 [/SUP], K Melmed[SUP] 1 4 [/SUP], S Galetta[SUP] 1 [/SUP], R Jain[SUP] 5 4 [/SUP]
Affiliations
- PMID: 33093131
- DOI: 10.3174/ajnr.A6898
Abstract
Background and purpose: Various patterns of leukoencephalopathy have been described in coronavirus disease 2019 (COVID-19). In this article, we aimed to describe the clinical and imaging features of acute disseminated leukoencephalopathy in critically ill patients with COVID-19 and the imaging evolution during a short-term follow-up.
Materials and methods: We identified and reviewed the clinical data, laboratory results, imaging findings, and outcomes for 8 critically ill patients with COVID-19 with acute disseminated leukoencephalopathy.
Results: All patients demonstrated multiple areas of white matter changes in both cerebral hemispheres; 87.5% (7/8) of patients had a posterior predilection. Four patients (50%) had short-term follow-up imaging within a median of 17 days after the first MR imaging; they developed brain atrophy, and their white matter lesions evolved into necrotizing cystic cavitations. All (8/8) patients had inflammatory cytokine release syndrome as demonstrated by elevated interleukin-6, D-dimer, lactate dehydrogenase, erythrocyte sedimentation rate, C-reactive protein, and ferritin levels. Most (7/8; 87.5%) patients were on prolonged ventilator support (median, 44.5 days; interquartile range, 20.5 days). These patients had poor functional outcomes (6/8 [75%] patients were discharged with mRS 5) and high mortality (2/8, 25%).
Conclusions: Critically ill patients with COVID-19 can develop acute disseminated leukoencephalopathy that evolves into cystic degeneration of white matter lesions with brain atrophy during a short period, which we dubbed virus-associated necrotizing disseminated acute leukoencephalopathy. This may be the result of COVID-19-related endothelial injury, cytokine storm, or thrombotic microangiopathy.