tetano
Editor, Senior Moderator
Ageing Res Rev
. 2021 Apr 1;101337.
doi: 10.1016/j.arr.2021.101337. Online ahead of print.
Effects of influenza vaccination on clinical outcomes of chronic obstructive pulmonary disease: a systematic review and meta-analysis
Wanying Bao[SUP] 1 [/SUP], Ya Li[SUP] 1 [/SUP], Tao Wang[SUP] 1 [/SUP], Xiaoou Li[SUP] 1 [/SUP], Junyun He[SUP] 2 [/SUP], Yashu Wang[SUP] 3 [/SUP], Fuqiang Wen[SUP] 4 [/SUP], Jun Chen[SUP] 5 [/SUP]
Affiliations
Abstract
Purpose: Influenza is a threat to patients with chronic obstructive pulmonary disease (COPD), influenza vaccination help to reduce incidence of influenza infection, however, whether it is beneficial to COPD patients in clinical outcomes lacks for evidence due to limited studies and participations.
Methods: We searched PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI) and China Science and Technology Journal Database (CSTJ) to retrieve eligible studies regardless of study design published before August 2020, and conducted meta-analysis with odds ratio (OR) and mean difference (MD). The quality of included studies and pooled evidences were assessed. Narrative summaries were provided where data were insufficient for meta-analysis.
Results: 2831 COPD patients were included, the pooled results showed that influenza vaccination reduced the exacerbations (P = 0.0001) and trends of hospitalizations (P = 0.09) in COPD patients. Further subgroup analysis showed that the reduction of exacerbations and hospitalizations were significant in patients with FEV[SUB]1[/SUB]<50% predicted (P = 0.01 and P < 0.0001 respectively), but not in those with FEV[SUB]1[/SUB]?50% predicted (P = 0.23 and P = 0.76 respectively). No significant effect of influenza vaccination on all-cause mortality was observed.
Conclusions: Our findings support a protective role of influenza vaccination in COPD patients, a yearly influenza vaccination should be strongly recommended for all COPD patients, especially those with severe airflow limitation, to reduce possible influenza infection, and thus associated exacerbations and hospitalizations.
Keywords: Acute exacerbation; All-cause mortality; Chronic obstructive pulmonary disease; Forced expiratory volume in 1 second; Hospital admissions; Influenza vaccination.
. 2021 Apr 1;101337.
doi: 10.1016/j.arr.2021.101337. Online ahead of print.
Effects of influenza vaccination on clinical outcomes of chronic obstructive pulmonary disease: a systematic review and meta-analysis
Wanying Bao[SUP] 1 [/SUP], Ya Li[SUP] 1 [/SUP], Tao Wang[SUP] 1 [/SUP], Xiaoou Li[SUP] 1 [/SUP], Junyun He[SUP] 2 [/SUP], Yashu Wang[SUP] 3 [/SUP], Fuqiang Wen[SUP] 4 [/SUP], Jun Chen[SUP] 5 [/SUP]
Affiliations
- PMID: 33813014
- DOI: 10.1016/j.arr.2021.101337
Abstract
Purpose: Influenza is a threat to patients with chronic obstructive pulmonary disease (COPD), influenza vaccination help to reduce incidence of influenza infection, however, whether it is beneficial to COPD patients in clinical outcomes lacks for evidence due to limited studies and participations.
Methods: We searched PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI) and China Science and Technology Journal Database (CSTJ) to retrieve eligible studies regardless of study design published before August 2020, and conducted meta-analysis with odds ratio (OR) and mean difference (MD). The quality of included studies and pooled evidences were assessed. Narrative summaries were provided where data were insufficient for meta-analysis.
Results: 2831 COPD patients were included, the pooled results showed that influenza vaccination reduced the exacerbations (P = 0.0001) and trends of hospitalizations (P = 0.09) in COPD patients. Further subgroup analysis showed that the reduction of exacerbations and hospitalizations were significant in patients with FEV[SUB]1[/SUB]<50% predicted (P = 0.01 and P < 0.0001 respectively), but not in those with FEV[SUB]1[/SUB]?50% predicted (P = 0.23 and P = 0.76 respectively). No significant effect of influenza vaccination on all-cause mortality was observed.
Conclusions: Our findings support a protective role of influenza vaccination in COPD patients, a yearly influenza vaccination should be strongly recommended for all COPD patients, especially those with severe airflow limitation, to reduce possible influenza infection, and thus associated exacerbations and hospitalizations.
Keywords: Acute exacerbation; All-cause mortality; Chronic obstructive pulmonary disease; Forced expiratory volume in 1 second; Hospital admissions; Influenza vaccination.