tetano
Editor, Senior Moderator
Adv Exp Med Biol
. 2022;1395:99-103.
doi: 10.1007/978-3-031-14190-4_17.
Pulmonary Embolism in COVID-19 Patients Is Not Related to a Deterioration of Tissue Oxygenation
Sebastiano Cicco[SUP] 1 [/SUP], F Albanese[SUP] 2 [/SUP], R Didonna[SUP] 2 [/SUP], A Magistro[SUP] 2 [/SUP], A Vacca[SUP] 3 [/SUP], C Cariddi[SUP] 4 [/SUP], G Lauletta[SUP] 2 [/SUP], F Pappagallo[SUP] 2 [/SUP], A G Solimando[SUP] 2 [/SUP], R Ria[SUP] 2 [/SUP]
Affiliations
Abstract
Background: COVID-19 induces robust systemic inflammation. One of the main complications is the increased coagulation due to endotheliitis. There is an increased incidence of pulmonary embolism (PE) in COVID-19 patients. However, clinical characteristics for a strict analysis are yet to be determined.
Aim: We evaluated oxygenation and characteristics in patients with COVID-19 PE (CPE).
Material and methods: We evaluated 215 COVID-19 patients from 1 January to 30 April 2021. We found 18 patients affected by PE (CPE, 50.0% males, aged 67.00 ± 10.86 years). As controls, we used data from patients affected by PE evaluated in our ward between 1 January 2015 and 31 December 2019 (64 patients, 53.1% males, aged 70.88 ± 16.44 years). All patients underwent a complete physical examination, pulmonary computerised tomography, laboratory tests, D-dimers and blood gas analysis at the time of diagnosis.
Results: There were no differences in laboratory tests nor in D-dimers between the two groups. In the CPE group we found a significantly increased pO[SUB]2[/SUB] (92.83 ± 42.52 vs. 76.11 ± 32.58 mmHg; p < 0.05), difference of oxygen between alveoli and arteries (A-aDO[SUB]2[/SUB]; 169.3 ± 171.9 vs. 52.97 ± 39.65 mmHg; p < 0.05), and oxygen saturation % (97.06 ± 2.59 vs. 93.77 ± 5.53%; p < 0.05) compared to controls. No difference was found in pCO[SUB]2[/SUB] and the ratio between pO[SUB]2[/SUB] and percentage of inspired oxygen (P/F). Finally, a significantly decreased urate (3.67 ± 1.49 vs. 5.60 ± 2.10; p < 0.05) was found in CPE compared to controls. In CPE, platelets count presents an inverse correlation to P/F (r = -0.389, p = 0.02) but a direct correlation to A-aDO[SUB]2[/SUB] (r = 0.699, p = 0.001). No similar findings were present in controls.
Discussion: COVID-19 PE appears to have a different clinical setting. Reduced oxygenation described in PE may not to be considered as a sign of disease. The increased A-aDO[SUB]2[/SUB] may indicate that COVID-19 PE involved smaller vessels compared to classical PE. A possible diffuse capillary thrombosis could explain these results.
Keywords: Endotheliitis; Platelet counts; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2); Systemic inflammation.
. 2022;1395:99-103.
doi: 10.1007/978-3-031-14190-4_17.
Pulmonary Embolism in COVID-19 Patients Is Not Related to a Deterioration of Tissue Oxygenation
Sebastiano Cicco[SUP] 1 [/SUP], F Albanese[SUP] 2 [/SUP], R Didonna[SUP] 2 [/SUP], A Magistro[SUP] 2 [/SUP], A Vacca[SUP] 3 [/SUP], C Cariddi[SUP] 4 [/SUP], G Lauletta[SUP] 2 [/SUP], F Pappagallo[SUP] 2 [/SUP], A G Solimando[SUP] 2 [/SUP], R Ria[SUP] 2 [/SUP]
Affiliations
- PMID: 36527621
- DOI: 10.1007/978-3-031-14190-4_17
Abstract
Background: COVID-19 induces robust systemic inflammation. One of the main complications is the increased coagulation due to endotheliitis. There is an increased incidence of pulmonary embolism (PE) in COVID-19 patients. However, clinical characteristics for a strict analysis are yet to be determined.
Aim: We evaluated oxygenation and characteristics in patients with COVID-19 PE (CPE).
Material and methods: We evaluated 215 COVID-19 patients from 1 January to 30 April 2021. We found 18 patients affected by PE (CPE, 50.0% males, aged 67.00 ± 10.86 years). As controls, we used data from patients affected by PE evaluated in our ward between 1 January 2015 and 31 December 2019 (64 patients, 53.1% males, aged 70.88 ± 16.44 years). All patients underwent a complete physical examination, pulmonary computerised tomography, laboratory tests, D-dimers and blood gas analysis at the time of diagnosis.
Results: There were no differences in laboratory tests nor in D-dimers between the two groups. In the CPE group we found a significantly increased pO[SUB]2[/SUB] (92.83 ± 42.52 vs. 76.11 ± 32.58 mmHg; p < 0.05), difference of oxygen between alveoli and arteries (A-aDO[SUB]2[/SUB]; 169.3 ± 171.9 vs. 52.97 ± 39.65 mmHg; p < 0.05), and oxygen saturation % (97.06 ± 2.59 vs. 93.77 ± 5.53%; p < 0.05) compared to controls. No difference was found in pCO[SUB]2[/SUB] and the ratio between pO[SUB]2[/SUB] and percentage of inspired oxygen (P/F). Finally, a significantly decreased urate (3.67 ± 1.49 vs. 5.60 ± 2.10; p < 0.05) was found in CPE compared to controls. In CPE, platelets count presents an inverse correlation to P/F (r = -0.389, p = 0.02) but a direct correlation to A-aDO[SUB]2[/SUB] (r = 0.699, p = 0.001). No similar findings were present in controls.
Discussion: COVID-19 PE appears to have a different clinical setting. Reduced oxygenation described in PE may not to be considered as a sign of disease. The increased A-aDO[SUB]2[/SUB] may indicate that COVID-19 PE involved smaller vessels compared to classical PE. A possible diffuse capillary thrombosis could explain these results.
Keywords: Endotheliitis; Platelet counts; Severe acute respiratory syndrome coronavirus 2 (SARS-CoV2); Systemic inflammation.