tetano
Editor, Senior Moderator
Med Intensiva. 2010 May 21. [Epub ahead of print]
[Acute respiratory distress syndrome during the 2009 H1N1 influenza A pandemic in Ecuador.]
[Article in Spanish]
Paredes G, Cevallos C.
Unidad de Cuidados Intensivos, Hospital Enrique Garc?s, Quito, Ecuador.
Abstract
OBJECTIVE: Among the most severe complications caused by the influenza A virus H1N1 pandemic is the Acute Respiratory Distress Syndrome (ARDS). The main objective of this study was to assess mortality after applying a strict protocol of ventilatory management and to describe the clinical characteristics of the patients. DESIGN: A prospective cohort study. SETTING: Intensive care unit (ICU) of the Hospital Enrique Garc?s of the City of Quito. PATIENTS: Patients admitted to the ICU with a diagnosis of severe pneumonia, ARDS, and high suspicion of influenza A H1N1. PRIMARY VARIABLES OF INTEREST: Demographic variables, severity, diagnostic scores of community-acquired pneumonia, ventilator management protocol and mortality at 28 days, as principal effect of the study, were collected. RESULTS: 24 patients were studied, 100% with a diagnosis of ARDS, mean age 41.1 (+/-14.8). Severe viral pneumonia predominated in these patients, mean APACHE was 18, average PaO(2)/FiO(2) on admission was 74.9, 100% had multisystemic involvement. A total of 91.3% received oseltamivir 150mg w/12h for 14 days, the mean time between onset of symptoms and antiviral administration was 6.74 days. Intra-ICU mortality was 16.6%, and 28 days was 16.6%. CONCLUSIONS: After applying a strict management protocol for ventilatory management, mortality in this patient group was 16.6. We also stress that obesity and early renal failure were independent risk factors for mortality. Copyright ? 2009 Elsevier Espa?a, S.L. y SEMICYUC. All rights reserved.
PMID: 20546973 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/20546973
[Acute respiratory distress syndrome during the 2009 H1N1 influenza A pandemic in Ecuador.]
[Article in Spanish]
Paredes G, Cevallos C.
Unidad de Cuidados Intensivos, Hospital Enrique Garc?s, Quito, Ecuador.
Abstract
OBJECTIVE: Among the most severe complications caused by the influenza A virus H1N1 pandemic is the Acute Respiratory Distress Syndrome (ARDS). The main objective of this study was to assess mortality after applying a strict protocol of ventilatory management and to describe the clinical characteristics of the patients. DESIGN: A prospective cohort study. SETTING: Intensive care unit (ICU) of the Hospital Enrique Garc?s of the City of Quito. PATIENTS: Patients admitted to the ICU with a diagnosis of severe pneumonia, ARDS, and high suspicion of influenza A H1N1. PRIMARY VARIABLES OF INTEREST: Demographic variables, severity, diagnostic scores of community-acquired pneumonia, ventilator management protocol and mortality at 28 days, as principal effect of the study, were collected. RESULTS: 24 patients were studied, 100% with a diagnosis of ARDS, mean age 41.1 (+/-14.8). Severe viral pneumonia predominated in these patients, mean APACHE was 18, average PaO(2)/FiO(2) on admission was 74.9, 100% had multisystemic involvement. A total of 91.3% received oseltamivir 150mg w/12h for 14 days, the mean time between onset of symptoms and antiviral administration was 6.74 days. Intra-ICU mortality was 16.6%, and 28 days was 16.6%. CONCLUSIONS: After applying a strict management protocol for ventilatory management, mortality in this patient group was 16.6. We also stress that obesity and early renal failure were independent risk factors for mortality. Copyright ? 2009 Elsevier Espa?a, S.L. y SEMICYUC. All rights reserved.
PMID: 20546973 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/20546973