tetano
Editor, Senior Moderator
Ann Agric Environ Med. 2013 Dec 19;20(4):711-4.
Acute respiratory distress syndrome (ARDS) in the course of influenza A/H1N1v infection - genetic aspects.
Niemcewicz M1, Pająk B2, Michalski A1, Kocik J1, Kołodziej M1, Joniec J1, Graniak G1, Gaweł J1, Marciniak-Niemcewicz A3, Kucharczyk K4, Prystupa A5, Witczak A5, Lasocki K1, Naylor K3, Goniewicz M3.
Author information
Abstract
Influenza is a contagious respiratory disease caused by viruses belonging to the family Ortomyxoviridae. Among the influenza viruses type A, B and C, the A type virus shows the most pathogenic potential. Its surface receptor glycoproteins, hemagglutinin (HA) and neuraminidase (NA), are characterized by high antigenic variation, thus a host organism cannot develop permanent resistance. The case is described of a male patient with severe acute respiratory distress syndrome in the course of influenza A/N1H1v infection, confirmed by virological molecular analysis. During diagnostic procedures based on the MSSCP genotyping it was observed that the WHO recommended RT-PCR kits and/or procedure of sample collection from patients for molecular investigation could lead to false positive A/H1N1 pandemic strain detection because of the co-amplification during the RT-PCR fragments of the human genome.
PMID:
24364440
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/24364440
Acute respiratory distress syndrome (ARDS) in the course of influenza A/H1N1v infection - genetic aspects.
Niemcewicz M1, Pająk B2, Michalski A1, Kocik J1, Kołodziej M1, Joniec J1, Graniak G1, Gaweł J1, Marciniak-Niemcewicz A3, Kucharczyk K4, Prystupa A5, Witczak A5, Lasocki K1, Naylor K3, Goniewicz M3.
Author information
Abstract
Influenza is a contagious respiratory disease caused by viruses belonging to the family Ortomyxoviridae. Among the influenza viruses type A, B and C, the A type virus shows the most pathogenic potential. Its surface receptor glycoproteins, hemagglutinin (HA) and neuraminidase (NA), are characterized by high antigenic variation, thus a host organism cannot develop permanent resistance. The case is described of a male patient with severe acute respiratory distress syndrome in the course of influenza A/N1H1v infection, confirmed by virological molecular analysis. During diagnostic procedures based on the MSSCP genotyping it was observed that the WHO recommended RT-PCR kits and/or procedure of sample collection from patients for molecular investigation could lead to false positive A/H1N1 pandemic strain detection because of the co-amplification during the RT-PCR fragments of the human genome.
PMID:
24364440
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/24364440