tetano
Editor, Senior Moderator
Acute Crit Care
. 2023 Nov;38(4):425-434.
doi: 10.4266/acc.2023.00773. Epub 2023 Nov 28. Healthcare-associated infections in critical COVID-19 patients in Tunis: epidemiology, risk factors, and outcomes
Ahlem Trifi[SUP] 1 [/SUP], Selim Sellaouti[SUP] 1 [/SUP], Asma Mehdi[SUP] 1 [/SUP], Lynda Messaoud[SUP] 1 [/SUP], Eya Seghir[SUP] 1 [/SUP], Badis Tlili[SUP] 1 [/SUP], Sami Abdellatif[SUP] 1 [/SUP]
Affiliations
Background: Coronavirus disease 2019 (COVID-19) pandemic disrupted adherences to healthcare-associated infection (HAI) prevention protocols. Herein, we studied the characteristics of all HAIs occurring in critically ill COVID-19 patients.
Methods: A retrospective, single-center cohort of critical COVID-19 patients during 2021. Microbiological samples were collected if HAI was suspected. We analyzed all factors that could potentially induce HAI, using septic shock and mortality as endpoints.
Results: Sixty-four among 161 included patients (39.7%) presented a total of 117 HAIs with an incidence density of 69.2 per 1,000 hospitalization days. Compared to the prior COVID-19 period (2013-2019), the identification of HAI increased in 2021. HAIs were classified into ventilator-associated pneumonia (VAP; n=38), bloodstream infection (n=32), urinary tract infection (n=24), catheter-related infection (n=12), and fungal infection (n=11). All HAIs occurred significantly earlier in the post-COVID-19 period (VAP: 6 vs. 10 days, P=0.045, in 2017 and 2021). Acinetobacter baumannii (39.5%) and Klebsiella pneumoniae (27%) were the most commonly isolated pathogens that exhibited a multidrug-resistant (MDR) profile, observed in 89% and 64.5%, respectively. The HAI factors were laboratory abnormalities (odds ratio [OR], 6.4; 95% confidence interval [CI], 2.3-26.0), cumulative steroid dose (OR, 1.9; 95% CI, 1.3-4.0), and invasive procedures (OR, 20.7; 95% CI, 5.3-64.0). HAI was an independent factor of mortality (OR, 8.5; P=0.004).
Conclusions: During the COVID-19 era, the incidence of HAIs increased and MDR isolates remained frequent. A severe biological inflammatory syndrome, invasive devices, and elevated cumulative steroid dosages were related to HAIs. HAI was a significant death factor.
Keywords: COVID-19; critical care; epidemiology; healthcare-associated infections; prognosis.
. 2023 Nov;38(4):425-434.
doi: 10.4266/acc.2023.00773. Epub 2023 Nov 28. Healthcare-associated infections in critical COVID-19 patients in Tunis: epidemiology, risk factors, and outcomes
Ahlem Trifi[SUP] 1 [/SUP], Selim Sellaouti[SUP] 1 [/SUP], Asma Mehdi[SUP] 1 [/SUP], Lynda Messaoud[SUP] 1 [/SUP], Eya Seghir[SUP] 1 [/SUP], Badis Tlili[SUP] 1 [/SUP], Sami Abdellatif[SUP] 1 [/SUP]
Affiliations
- PMID: 38052509
- DOI: 10.4266/acc.2023.00773
Background: Coronavirus disease 2019 (COVID-19) pandemic disrupted adherences to healthcare-associated infection (HAI) prevention protocols. Herein, we studied the characteristics of all HAIs occurring in critically ill COVID-19 patients.
Methods: A retrospective, single-center cohort of critical COVID-19 patients during 2021. Microbiological samples were collected if HAI was suspected. We analyzed all factors that could potentially induce HAI, using septic shock and mortality as endpoints.
Results: Sixty-four among 161 included patients (39.7%) presented a total of 117 HAIs with an incidence density of 69.2 per 1,000 hospitalization days. Compared to the prior COVID-19 period (2013-2019), the identification of HAI increased in 2021. HAIs were classified into ventilator-associated pneumonia (VAP; n=38), bloodstream infection (n=32), urinary tract infection (n=24), catheter-related infection (n=12), and fungal infection (n=11). All HAIs occurred significantly earlier in the post-COVID-19 period (VAP: 6 vs. 10 days, P=0.045, in 2017 and 2021). Acinetobacter baumannii (39.5%) and Klebsiella pneumoniae (27%) were the most commonly isolated pathogens that exhibited a multidrug-resistant (MDR) profile, observed in 89% and 64.5%, respectively. The HAI factors were laboratory abnormalities (odds ratio [OR], 6.4; 95% confidence interval [CI], 2.3-26.0), cumulative steroid dose (OR, 1.9; 95% CI, 1.3-4.0), and invasive procedures (OR, 20.7; 95% CI, 5.3-64.0). HAI was an independent factor of mortality (OR, 8.5; P=0.004).
Conclusions: During the COVID-19 era, the incidence of HAIs increased and MDR isolates remained frequent. A severe biological inflammatory syndrome, invasive devices, and elevated cumulative steroid dosages were related to HAIs. HAI was a significant death factor.
Keywords: COVID-19; critical care; epidemiology; healthcare-associated infections; prognosis.