tetano
Editor, Senior Moderator
Acta Gastroenterol Belg
. 2022 Jun 21;85(4):1-3.
doi: 10.51821/85.4.9032. Online ahead of print.
Pancreatitis, pregestational diabetes and hyperchylomicronia in a pregnant woman with COVID-19
S Laurijssen[SUP] 1 [/SUP], C Blanchaert[SUP] 1 [/SUP], ThB Twickler[SUP] 2 [/SUP], K Dam[SUP] 3 [/SUP]
Affiliations
Abstract
A 37-year-old pregnant woman, was diagnosed with acute pancreatitis whilst being infected with COVID-19. Additionally, she had a hyperchylomicronemia and an uncontrolled (most probably, pre-gestational) type 2 diabetes. The coronavirus is able to enter the pancreatic cells through ACE-2 receptors. On the pancreatic level, ACE- 2 receptor expression is present but not as abundant as on pulmonary level. However, with inflammation (due to hyperchylomicronemia), the ACE-2 receptor expression may change and hypothetically make the pancreas more susceptible for a Covid-19 surinfection. Here it is difficult to conclude whether the COVID-19 infection contributed substantially to the development of pancreatitis. Late term pregnancy, uncontrolled glycaemia and the heterozygote mutation in the GPIHBP1 gene (c.523G>C p; Gly175Arg), all contribute to increased TG levels, a principal factor in the development of pancreatitis. This case shows a rare but serious clinical presentation late in pregnancy that could have interesting consequences postpartum.
Keywords: COVID-19; GPIHBP1 gene; hyperchylomicronemia; pancreatitis; pregestational diabetes.
. 2022 Jun 21;85(4):1-3.
doi: 10.51821/85.4.9032. Online ahead of print.
Pancreatitis, pregestational diabetes and hyperchylomicronia in a pregnant woman with COVID-19
S Laurijssen[SUP] 1 [/SUP], C Blanchaert[SUP] 1 [/SUP], ThB Twickler[SUP] 2 [/SUP], K Dam[SUP] 3 [/SUP]
Affiliations
- PMID: 35770288
- DOI: 10.51821/85.4.9032
Abstract
A 37-year-old pregnant woman, was diagnosed with acute pancreatitis whilst being infected with COVID-19. Additionally, she had a hyperchylomicronemia and an uncontrolled (most probably, pre-gestational) type 2 diabetes. The coronavirus is able to enter the pancreatic cells through ACE-2 receptors. On the pancreatic level, ACE- 2 receptor expression is present but not as abundant as on pulmonary level. However, with inflammation (due to hyperchylomicronemia), the ACE-2 receptor expression may change and hypothetically make the pancreas more susceptible for a Covid-19 surinfection. Here it is difficult to conclude whether the COVID-19 infection contributed substantially to the development of pancreatitis. Late term pregnancy, uncontrolled glycaemia and the heterozygote mutation in the GPIHBP1 gene (c.523G>C p; Gly175Arg), all contribute to increased TG levels, a principal factor in the development of pancreatitis. This case shows a rare but serious clinical presentation late in pregnancy that could have interesting consequences postpartum.
Keywords: COVID-19; GPIHBP1 gene; hyperchylomicronemia; pancreatitis; pregestational diabetes.