tetano
Editor, Senior Moderator
ACS Infect Dis
. 2020 Dec 4.
doi: 10.1021/acsinfecdis.0c00726. Online ahead of print.
Antibodies That Engage the Hemagglutinin Receptor-Binding Site of Influenza B Viruses
Goran Bajic[SUP] 1 2 [/SUP], Stephen C Harrison[SUP] 1 3 [/SUP]
Affiliations
Abstract
We describe cross-reactive human antibodies recognizing influenza B viruses spanning nearly 80 years of antigenic drift. Structures show that they engage the receptor-binding site (RBS) of the viral hemagglutinin with strong similarities to their influenza A counterparts, despite structural differences between the RBS of influenza A and B. Our data show that these antibodies readily cross-react with both influenza B Victoria and Yamagata lineages. We also note that all antibodies are encoded by IGHV3-9/IGK1-33. Future research will provide insight into the prevalence of these antibodies in the human population.
Keywords: B-cell memory; hemagglutinin; influenza vaccine.
. 2020 Dec 4.
doi: 10.1021/acsinfecdis.0c00726. Online ahead of print.
Antibodies That Engage the Hemagglutinin Receptor-Binding Site of Influenza B Viruses
Goran Bajic[SUP] 1 2 [/SUP], Stephen C Harrison[SUP] 1 3 [/SUP]
Affiliations
- PMID: 33274930
- DOI: 10.1021/acsinfecdis.0c00726
Abstract
We describe cross-reactive human antibodies recognizing influenza B viruses spanning nearly 80 years of antigenic drift. Structures show that they engage the receptor-binding site (RBS) of the viral hemagglutinin with strong similarities to their influenza A counterparts, despite structural differences between the RBS of influenza A and B. Our data show that these antibodies readily cross-react with both influenza B Victoria and Yamagata lineages. We also note that all antibodies are encoded by IGHV3-9/IGK1-33. Future research will provide insight into the prevalence of these antibodies in the human population.
Keywords: B-cell memory; hemagglutinin; influenza vaccine.