A recombinant viruslike particle influenza A (H7N9) vaccine. N Engl J Med

[Biological]

Fries LF, Smith GE, Glenn GM. A recombinant viruslike particle influenza A (H7N9) vaccine. N Engl J Med 2013;369:2564-6. DOI: 10.1056/NEJMc1313186
December 26,

To the Editor:

Avian-origin influenza A (H7N9) viruses emerged as human pathogens in China in 2013 and have caused 137 cases and 45 deaths to date.1 These viruses have acquired mutations that could facilitate infection in mammals,2 which could pose a pandemic threat if the viruses become readily transmissible in humans. Vaccines are a key defense against pandemics, but candidate vaccines featuring H7 hemagglutinins (HA) have been poorly immunogenic...


A Recombinant Viruslike Particle Influenza A (H7N9) Vaccine — NEJM
http://www.nejm.org/doi/full/10.1056/NEJMc1313186?query=TOC
http://www.nejm.org/doi/pdf/10.1056/NEJMc1313186



Supplementary Appendix
This appendix has been provided by the authors to give readers additional information about their work.
Supplement to: Fries LF, Smith GE, Glenn GM. A recombinant viruslike particle influenza A (H7N9) vaccine.
N Engl J Med 2013;369:2564-6. DOI: 10.1056/NEJMc1313186

http://www.nejm.org/doi/suppl/10.1056/NEJMc1313186/suppl_file/nejmc1313186_appendix.pdf