tetano
Editor, Senior Moderator
J Virol. 2016 Jan 6. pii: JVI.03258-15. [Epub ahead of print]
[h=1]A recombinant adenovirus expressing ovine interferon-tau prevents influenza virus induced lethality in mice.[/h] Martin V[SUP]1[/SUP], Pascual E[SUP]2[/SUP], Avia M[SUP]2[/SUP], Rangel G[SUP]2[/SUP], de Molina A[SUP]3[/SUP], Alejo A[SUP]2[/SUP], Sevilla N[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Ovine interferon tau (IFN-τ) is a unique type I interferon with low toxicity and broad host range in vivo. We report the generation of a non replicative recombinant adenovirus expressing biologically active IFN-τ. Using the B6.A2G-Mx1 mouse model we show that a single dose intranasal administration of the recombinant Ad5-IFN-τ can effectively prevent highly virulent hv-PR8 influenza virus induced lethality and disease by activating the interferon response and preventing viral replication.
Copyright ? 2016, American Society for Microbiology. All Rights Reserved.
PMID: 26739058 [PubMed - as supplied by publisher]
[h=1]A recombinant adenovirus expressing ovine interferon-tau prevents influenza virus induced lethality in mice.[/h] Martin V[SUP]1[/SUP], Pascual E[SUP]2[/SUP], Avia M[SUP]2[/SUP], Rangel G[SUP]2[/SUP], de Molina A[SUP]3[/SUP], Alejo A[SUP]2[/SUP], Sevilla N[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Ovine interferon tau (IFN-τ) is a unique type I interferon with low toxicity and broad host range in vivo. We report the generation of a non replicative recombinant adenovirus expressing biologically active IFN-τ. Using the B6.A2G-Mx1 mouse model we show that a single dose intranasal administration of the recombinant Ad5-IFN-τ can effectively prevent highly virulent hv-PR8 influenza virus induced lethality and disease by activating the interferon response and preventing viral replication.
Copyright ? 2016, American Society for Microbiology. All Rights Reserved.
PMID: 26739058 [PubMed - as supplied by publisher]