tetano
Editor, Senior Moderator
Vaccine. 2010 Apr 12. [Epub ahead of print]
A randomized controlled trial of low-dose recombinant human interferons alpha-2b nasal spray to prevent acute viral respiratory infections in military recruits.
Gao L, Yu S, Chen Q, Duan Z, Zhou J, Mao C, Yu D, Zhu W, Nie J, Hou Y.
Department of Epidemiology, School of Public Health and Tropical Medicine, Southern Medical University, 1838 Guangzhou North Road, Guangzhou, 510515, Guangdong Province, China.
Abstract
The military population has a high disease burden of acute viral respiratory infections in China. To assess the efficacy and safety of a low-dose recombinant human interferon alpha-2b (rIFNalpha-2b) nasal spray in preventing acute viral respiratory infections in military population, we performed this randomized controlled trial. The results showed that application of the rIFNalpha-2b nasal spray had the benefits in prevention of infections caused by influenza A virus, influenza B virus parainfluenza viruses 1-3 and adenovirus species B. However, no benefit was seen in preventing respiratory syncytial virus. No severe adverse events were reported. Therefore, the rIFNalpha-2b nasal spray was effective and well tolerated for preventing common viral respiratory infections in the military recruits. Copyright ? 2010. Published by Elsevier Ltd.
PMID: 20394720 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/20394720?dopt=Abstract
A randomized controlled trial of low-dose recombinant human interferons alpha-2b nasal spray to prevent acute viral respiratory infections in military recruits.
Gao L, Yu S, Chen Q, Duan Z, Zhou J, Mao C, Yu D, Zhu W, Nie J, Hou Y.
Department of Epidemiology, School of Public Health and Tropical Medicine, Southern Medical University, 1838 Guangzhou North Road, Guangzhou, 510515, Guangdong Province, China.
Abstract
The military population has a high disease burden of acute viral respiratory infections in China. To assess the efficacy and safety of a low-dose recombinant human interferon alpha-2b (rIFNalpha-2b) nasal spray in preventing acute viral respiratory infections in military population, we performed this randomized controlled trial. The results showed that application of the rIFNalpha-2b nasal spray had the benefits in prevention of infections caused by influenza A virus, influenza B virus parainfluenza viruses 1-3 and adenovirus species B. However, no benefit was seen in preventing respiratory syncytial virus. No severe adverse events were reported. Therefore, the rIFNalpha-2b nasal spray was effective and well tolerated for preventing common viral respiratory infections in the military recruits. Copyright ? 2010. Published by Elsevier Ltd.
PMID: 20394720 [PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/20394720?dopt=Abstract