tetano
Editor, Senior Moderator
Cell Host Microbe. 2017 Oct 17. pii: S1931-3128(17)30396-7. doi: 10.1016/j.chom.2017.09.008. [Epub ahead of print]
[h=1]A Highly Pathogenic Avian H7N9 Influenza Virus Isolated from A Human Is Lethal in Some Ferrets Infected via Respiratory Droplets.[/h] Imai M[SUP]1[/SUP], Watanabe T[SUP]2[/SUP], Kiso M[SUP]2[/SUP], Nakajima N[SUP]3[/SUP], Yamayoshi S[SUP]2[/SUP], Iwatsuki-Horimoto K[SUP]2[/SUP], Hatta M[SUP]4[/SUP], Yamada S[SUP]2[/SUP], Ito M[SUP]2[/SUP], Sakai-Tagawa Y[SUP]2[/SUP], Shirakura M[SUP]5[/SUP], Takashita E[SUP]5[/SUP], Fujisaki S[SUP]5[/SUP], McBride R[SUP]6[/SUP], Thompson AJ[SUP]6[/SUP], Takahashi K[SUP]3[/SUP], Maemura T[SUP]2[/SUP], Mitake H[SUP]2[/SUP], Chiba S[SUP]4[/SUP], Zhong G[SUP]4[/SUP], Fan S[SUP]4[/SUP], Oishi K[SUP]2[/SUP], Yasuhara A[SUP]2[/SUP], Takada K[SUP]2[/SUP], Nakao T[SUP]2[/SUP], Fukuyama S[SUP]2[/SUP], Yamashita M[SUP]2[/SUP], Lopes TJS[SUP]7[/SUP], Neumann G[SUP]4[/SUP], Odagiri T[SUP]5[/SUP], Watanabe S[SUP]5[/SUP], Shu Y[SUP]8[/SUP], Paulson JC[SUP]6[/SUP], Hasegawa H[SUP]3[/SUP], Kawaoka Y[SUP]9[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Low pathogenic H7N9 influenza viruses have recently evolved to become highly pathogenic, raising concerns of a pandemic, particularly if these viruses acquire efficient human-to-human transmissibility. We compared a low pathogenic H7N9 virus with a highly pathogenic isolate, and two of its variants that represent neuraminidase inhibitor-sensitive and -resistant subpopulations detected within the isolate. The highly pathogenic H7N9 viruses replicated efficiently in mice, ferrets, and/or nonhuman primates, and were more pathogenic in mice and ferrets than the low pathogenic H7N9 virus, with the exception of the neuraminidase inhibitor-resistant virus, which showed mild-to-moderate attenuation. All viruses transmitted among ferrets via respiratory droplets, and the neuraminidase-sensitive variant killed several of the infected and exposed animals. Neuraminidase inhibitors showed limited effectiveness against these viruses in vivo, but the viruses were susceptible to a polymerase inhibitor. These results suggest that the highly pathogenic H7N9 virus has pandemic potential and should be closely monitored.
Copyright ? 2017 Elsevier Inc. All rights reserved.
[h=4]KEYWORDS:[/h] antiviral sensitivity; ferrets; highly pathogenic avian influenza H7N9 viruses; mice; nonhuman primates; pathogenicity; receptor-binding specificity; replication capacity; transmissibility
PMID: 29056430 DOI: 10.1016/j.chom.2017.09.008
[h=1]A Highly Pathogenic Avian H7N9 Influenza Virus Isolated from A Human Is Lethal in Some Ferrets Infected via Respiratory Droplets.[/h] Imai M[SUP]1[/SUP], Watanabe T[SUP]2[/SUP], Kiso M[SUP]2[/SUP], Nakajima N[SUP]3[/SUP], Yamayoshi S[SUP]2[/SUP], Iwatsuki-Horimoto K[SUP]2[/SUP], Hatta M[SUP]4[/SUP], Yamada S[SUP]2[/SUP], Ito M[SUP]2[/SUP], Sakai-Tagawa Y[SUP]2[/SUP], Shirakura M[SUP]5[/SUP], Takashita E[SUP]5[/SUP], Fujisaki S[SUP]5[/SUP], McBride R[SUP]6[/SUP], Thompson AJ[SUP]6[/SUP], Takahashi K[SUP]3[/SUP], Maemura T[SUP]2[/SUP], Mitake H[SUP]2[/SUP], Chiba S[SUP]4[/SUP], Zhong G[SUP]4[/SUP], Fan S[SUP]4[/SUP], Oishi K[SUP]2[/SUP], Yasuhara A[SUP]2[/SUP], Takada K[SUP]2[/SUP], Nakao T[SUP]2[/SUP], Fukuyama S[SUP]2[/SUP], Yamashita M[SUP]2[/SUP], Lopes TJS[SUP]7[/SUP], Neumann G[SUP]4[/SUP], Odagiri T[SUP]5[/SUP], Watanabe S[SUP]5[/SUP], Shu Y[SUP]8[/SUP], Paulson JC[SUP]6[/SUP], Hasegawa H[SUP]3[/SUP], Kawaoka Y[SUP]9[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Low pathogenic H7N9 influenza viruses have recently evolved to become highly pathogenic, raising concerns of a pandemic, particularly if these viruses acquire efficient human-to-human transmissibility. We compared a low pathogenic H7N9 virus with a highly pathogenic isolate, and two of its variants that represent neuraminidase inhibitor-sensitive and -resistant subpopulations detected within the isolate. The highly pathogenic H7N9 viruses replicated efficiently in mice, ferrets, and/or nonhuman primates, and were more pathogenic in mice and ferrets than the low pathogenic H7N9 virus, with the exception of the neuraminidase inhibitor-resistant virus, which showed mild-to-moderate attenuation. All viruses transmitted among ferrets via respiratory droplets, and the neuraminidase-sensitive variant killed several of the infected and exposed animals. Neuraminidase inhibitors showed limited effectiveness against these viruses in vivo, but the viruses were susceptible to a polymerase inhibitor. These results suggest that the highly pathogenic H7N9 virus has pandemic potential and should be closely monitored.
Copyright ? 2017 Elsevier Inc. All rights reserved.
[h=4]KEYWORDS:[/h] antiviral sensitivity; ferrets; highly pathogenic avian influenza H7N9 viruses; mice; nonhuman primates; pathogenicity; receptor-binding specificity; replication capacity; transmissibility
PMID: 29056430 DOI: 10.1016/j.chom.2017.09.008