tetano
Editor, Senior Moderator
J Infect Dis. 2020 Apr 4. pii: jiaa159. doi: 10.1093/infdis/jiaa159. [Epub ahead of print]
A high fat diet increases influenza A virus-associated cardiovascular damage.
Siegers JY[SUP]1[/SUP], Novakovic B[SUP]2[/SUP], Hulme KD[SUP]3[/SUP], Marshall R[SUP]3[/SUP], Bloxham CJ[SUP]4[/SUP], Thomas WG[SUP]4[/SUP], Reichelt ME[SUP]4[/SUP], Leijten L[SUP]1[/SUP], van Run P[SUP]1[/SUP], Knox K[SUP]5[/SUP], Sokolowski KA[SUP]5[/SUP], Tse BWC[SUP]5[/SUP], Chew KY[SUP]3[/SUP], Christ AN[SUP]6[/SUP], Howe G[SUP]6[/SUP], Bruxner TJC[SUP]6[/SUP], Karolyi M[SUP]7[/SUP], Pawelka E[SUP]7[/SUP], Koch RM[SUP]8[/SUP], Bellmann-Weiler R[SUP]9[/SUP], Burkert F[SUP]9[/SUP], Weiss G[SUP]9[/SUP], Samanta RJ[SUP]10[/SUP], Openshaw PJM[SUP]11[/SUP], Bielefeldt-Ohmann H[SUP]3,[/SUP][SUP]12[/SUP], van Riel D[SUP]1[/SUP], Short KR[SUP]3,[/SUP][SUP]12[/SUP].
Author information
Abstract
BACKGROUND:
Influenza A virus (IAV) causes a wide range of extra-respiratory complications. However, the role of host factors in these complications of influenza virus infection remains to be defined.
METHODS:
Here, we sought to use transcriptional profiling, virology, histology and echocardiograms to investigate the role of a high fat diet in IAV associated cardiac damage.
RESULTS:
Transcriptional profiling showed that, compared to their low fat (LF) counterparts, mice fed a high fat (HF) diet had impairments in inflammatory signalling in the lung and heart after IAV infection. This was associated with increased viral titres in the heart, increased left ventricular mass and thickening of the left ventricular wall in IAV-infected HF mice compared to both IAV-infected LF mice and uninfected HF mice. Retrospective analysis of clinical trials revealed that cardiac complications were more common in patients with excess weight, an association which was significant in 2 out of 4 studies.
CONCLUSIONS:
Together, these data provide the first evidence that a high fat diet may be a risk factor for the development of IAV-associated cardiovascular damageand emphasises the need for further clinical research in this area.
? The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
KEYWORDS:
body mass index; cardiac disease; extra respiratory complications; high fat diet; influenza; obesity; overweight
PMID:32246148DOI:10.1093/infdis/jiaa159
A high fat diet increases influenza A virus-associated cardiovascular damage.
Siegers JY[SUP]1[/SUP], Novakovic B[SUP]2[/SUP], Hulme KD[SUP]3[/SUP], Marshall R[SUP]3[/SUP], Bloxham CJ[SUP]4[/SUP], Thomas WG[SUP]4[/SUP], Reichelt ME[SUP]4[/SUP], Leijten L[SUP]1[/SUP], van Run P[SUP]1[/SUP], Knox K[SUP]5[/SUP], Sokolowski KA[SUP]5[/SUP], Tse BWC[SUP]5[/SUP], Chew KY[SUP]3[/SUP], Christ AN[SUP]6[/SUP], Howe G[SUP]6[/SUP], Bruxner TJC[SUP]6[/SUP], Karolyi M[SUP]7[/SUP], Pawelka E[SUP]7[/SUP], Koch RM[SUP]8[/SUP], Bellmann-Weiler R[SUP]9[/SUP], Burkert F[SUP]9[/SUP], Weiss G[SUP]9[/SUP], Samanta RJ[SUP]10[/SUP], Openshaw PJM[SUP]11[/SUP], Bielefeldt-Ohmann H[SUP]3,[/SUP][SUP]12[/SUP], van Riel D[SUP]1[/SUP], Short KR[SUP]3,[/SUP][SUP]12[/SUP].
Author information
Abstract
BACKGROUND:
Influenza A virus (IAV) causes a wide range of extra-respiratory complications. However, the role of host factors in these complications of influenza virus infection remains to be defined.
METHODS:
Here, we sought to use transcriptional profiling, virology, histology and echocardiograms to investigate the role of a high fat diet in IAV associated cardiac damage.
RESULTS:
Transcriptional profiling showed that, compared to their low fat (LF) counterparts, mice fed a high fat (HF) diet had impairments in inflammatory signalling in the lung and heart after IAV infection. This was associated with increased viral titres in the heart, increased left ventricular mass and thickening of the left ventricular wall in IAV-infected HF mice compared to both IAV-infected LF mice and uninfected HF mice. Retrospective analysis of clinical trials revealed that cardiac complications were more common in patients with excess weight, an association which was significant in 2 out of 4 studies.
CONCLUSIONS:
Together, these data provide the first evidence that a high fat diet may be a risk factor for the development of IAV-associated cardiovascular damageand emphasises the need for further clinical research in this area.
? The Author(s) 2020. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
KEYWORDS:
body mass index; cardiac disease; extra respiratory complications; high fat diet; influenza; obesity; overweight
PMID:32246148DOI:10.1093/infdis/jiaa159