Mary Wilson
Well-known member
Published December 13, 2022
DOI:https://doi.org/10.1016/j.celrep.2022.111903
Jiandong Huo [SUP]# [/SUP]Aiste Dijokaite-Guraliuc [SUP]# [/SUP]Chang Liu [SUP]# [/SUP]Jingshan Ren David I. Stuart [SUP]ˆ [/SUP]Gavin R. Screaton
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Highlights
Variants of SARS CoV-2 have caused successive global waves of infection. These variants, with multiple mutations in the spike protein are thought to facilitate escape from natural and vaccine-induced immunity and often increase in the affinity for ACE2. The latest variant to cause concern is BA.2.75, identified in India where it is now the dominant strain, with evidence of wider dissemination. BA.2.75 is derived from BA.2 and contains four additional mutations in the receptor binding domain (RBD). Here we perform an antigenic and biophysical characterization of BA.2.75, revealing an interesting balance between humoral evasion and ACE2 receptor affinity. ACE2 affinity for BA.2.75 is increased 9-fold compared to BA.2; there is also evidence of escape of BA.2.75 from immune serum, particularly that induced by Delta infection which may explain the rapid spread in India, where BA.2.75 is now the dominant variant. ACE2 affinity appears to be prioritised over greater escape.
https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01802-2
DOI:https://doi.org/10.1016/j.celrep.2022.111903
Jiandong Huo [SUP]# [/SUP]Aiste Dijokaite-Guraliuc [SUP]# [/SUP]Chang Liu [SUP]# [/SUP]Jingshan Ren David I. Stuart [SUP]ˆ [/SUP]Gavin R. Screaton
Show all authors
Highlights
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BA.2.75 affinity for ACE2 is increased 9-fold compared to BA.2. - •
N460K increases neutralization escape and likely increases ACE2 affinity. - •
The revertant R493Q decreases neutralization escape but increases ACE2 affinity. - •
Affinity to ACE2 appears to be prioritized over neutralization escape.
Variants of SARS CoV-2 have caused successive global waves of infection. These variants, with multiple mutations in the spike protein are thought to facilitate escape from natural and vaccine-induced immunity and often increase in the affinity for ACE2. The latest variant to cause concern is BA.2.75, identified in India where it is now the dominant strain, with evidence of wider dissemination. BA.2.75 is derived from BA.2 and contains four additional mutations in the receptor binding domain (RBD). Here we perform an antigenic and biophysical characterization of BA.2.75, revealing an interesting balance between humoral evasion and ACE2 receptor affinity. ACE2 affinity for BA.2.75 is increased 9-fold compared to BA.2; there is also evidence of escape of BA.2.75 from immune serum, particularly that induced by Delta infection which may explain the rapid spread in India, where BA.2.75 is now the dominant variant. ACE2 affinity appears to be prioritised over greater escape.
https://www.cell.com/cell-reports/fulltext/S2211-1247(22)01802-2
