tetano
Editor, Senior Moderator
J Clin Virol. 2015 Oct;71:44-50. doi: 10.1016/j.jcv.2015.07.308. Epub 2015 Jul 29.
[h=1]A comparison of H1N1 influenza among pediatric inpatients in the pandemic and post pandemic era.[/h] Rao S[SUP]1[/SUP], Torok MR[SUP]2[/SUP], Bagdure D[SUP]3[/SUP], Cunningham MA[SUP]4[/SUP], Williams JT[SUP]5[/SUP], Curtis DJ[SUP]6[/SUP], Wilson K[SUP]4[/SUP], Dominguez SR[SUP]6[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] The novel influenza A H1N1 (A[H1N1]pdm09) strain emerged in 2009, contributing to significant morbidity and mortality. It is not known whether illness associated with A(H1N1) pdm09 in the post-pandemic era exhibits a similar disease profile.
[h=4]OBJECTIVE:[/h] The objectives of this study were to compare the burden of disease of A(H1N1) pdm09 influenza from the 2009 pandemic year to the post-pandemic years (2010-2014), and to explore potential reasons for any differences.
[h=4]STUDY DESIGN:[/h] We conducted a retrospective cohort study of inpatients admitted to Children's Hospital Colorado with a positive respiratory specimen for influenza from May-December, 2009 and December, 2010-April, 2014. Univariate and multivariate analyses were conducted to compare the demographics and clinical characteristics of patients with H1N1 during the two periods.
[h=4]RESULTS:[/h] There were 388 inpatients with influenza A(H1N1) pdm09 in 2009, and 117 during the post-pandemic years. Ninety-four percent of all H1N1 during the post-pandemic era was observed during the 2013-2014 influenza season. Patients with A(H1N1) pdm09 during the post-pandemic year were less likely to have an underlying medical condition (P<0.01). Patients admitted to the ICU during the post-pandemic year had a lower median age (5 vs 8 years, P=0.01) and a lower proportion of patients were intubated, had mental status changes, and ARDS compared with the pandemic years, (P<0.01 for all), with decreased mortality (P=0.02).
[h=4]CONCLUSION:[/h] Patients with influenza A(H1N1) pdm09 during the post-pandemic years appeared to have less severe disease than patients with A(H1N1) pdm09 during the pandemic year. The reasons for this difference are likely multifactorial.
Published by Elsevier B.V.
[h=4]KEYWORDS:[/h] H1N1; Influenza; Inpatients; Pandemic; Post-pandemic period
PMID: 26370314 [PubMed - in process]
[h=1]A comparison of H1N1 influenza among pediatric inpatients in the pandemic and post pandemic era.[/h] Rao S[SUP]1[/SUP], Torok MR[SUP]2[/SUP], Bagdure D[SUP]3[/SUP], Cunningham MA[SUP]4[/SUP], Williams JT[SUP]5[/SUP], Curtis DJ[SUP]6[/SUP], Wilson K[SUP]4[/SUP], Dominguez SR[SUP]6[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] The novel influenza A H1N1 (A[H1N1]pdm09) strain emerged in 2009, contributing to significant morbidity and mortality. It is not known whether illness associated with A(H1N1) pdm09 in the post-pandemic era exhibits a similar disease profile.
[h=4]OBJECTIVE:[/h] The objectives of this study were to compare the burden of disease of A(H1N1) pdm09 influenza from the 2009 pandemic year to the post-pandemic years (2010-2014), and to explore potential reasons for any differences.
[h=4]STUDY DESIGN:[/h] We conducted a retrospective cohort study of inpatients admitted to Children's Hospital Colorado with a positive respiratory specimen for influenza from May-December, 2009 and December, 2010-April, 2014. Univariate and multivariate analyses were conducted to compare the demographics and clinical characteristics of patients with H1N1 during the two periods.
[h=4]RESULTS:[/h] There were 388 inpatients with influenza A(H1N1) pdm09 in 2009, and 117 during the post-pandemic years. Ninety-four percent of all H1N1 during the post-pandemic era was observed during the 2013-2014 influenza season. Patients with A(H1N1) pdm09 during the post-pandemic year were less likely to have an underlying medical condition (P<0.01). Patients admitted to the ICU during the post-pandemic year had a lower median age (5 vs 8 years, P=0.01) and a lower proportion of patients were intubated, had mental status changes, and ARDS compared with the pandemic years, (P<0.01 for all), with decreased mortality (P=0.02).
[h=4]CONCLUSION:[/h] Patients with influenza A(H1N1) pdm09 during the post-pandemic years appeared to have less severe disease than patients with A(H1N1) pdm09 during the pandemic year. The reasons for this difference are likely multifactorial.
Published by Elsevier B.V.
[h=4]KEYWORDS:[/h] H1N1; Influenza; Inpatients; Pandemic; Post-pandemic period
PMID: 26370314 [PubMed - in process]