J. Virol. Indications that Live Poultry Markets are a Major Source of Human H5N1 Influenza Virus Infection in China

Laidback Al · Oct 7, 2011

J. Virol. doi:10.1128/JVI.05266-11
Copyright ? 2011,American Society for Microbiology and/or the Listed
Authors/Institutions. All Rights Reserved.

Indications that Live Poultry Markets are a Major Source of Human H5N1 Influenza Virus Infection in China
Xiu-Feng Wan1,2, Libo Dong1, Yu Lan1, Li-Ping Long2, Cuiling Xu1, Shumei Zou1, Zi Li1, Leying Wen1, Zhipeng Cai2, Wei Wang1, Xiaodan Li1, Fan Yuan1, Hongtao Sui1, Ye Zhang1, Jie Dong1, Shanhua Sun1, Yan Gao1, Min Wang1, Tian Bai1, Lei Yang1, Dexin Li1, Weizhong Yang3, Hongjie Yu3, Shiwen Wang1, Zijian Feng3, Yu Wang3, Yuanji Guo1, Richard J. Webby4, andYuelong Shu1,*

ABSTRACT

Human infections of H5N1 highly pathogenic avian influenza virus have continued to occur in China without corresponding outbreaks in poultry, and there is little conclusive evidence of the source of these infections. Seeking to identify the source of the human infections, we sequenced 31 H5N1 viruses isolated from humans in China (2005-2010). We found a number of viral genotypes, not all of which having similar known avian virus counterparts. Guided by patient questionnaire data, we also obtained environmental samples from live poultry markets and dwellings frequented by six individuals prior to disease onset (2008-2009). H5N1 viruses were isolated from 4 of the 6 live poultry markets sampled. In each case, the genetic sequence of the environmental and corresponding human isolates was highly similar, demonstrating a link between human infection and live poultry markets. Therefore, infection control measures in live poultry markets are likely to reduce human H5N1 infection in China.

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full article in pdf at PDF

Wan, X.-F., L. Dong, Y. Lan, L.-P. Long, C. Xu, S. Zou, Z. Li, L. Wen, Z. Cai, W. Wang, X. Li, F. Yuan, H. Sui, Y. Zhang, J. Dong, S. Sun, Y. Gao, M. Wang, T. Bai, L. Yang, D. Li, W. Yang, H. Yu, S. Wang, Z. Feng, Y. Wang, Y. Guo, R. J. Webby, and Y. Shu. 2011. Indications that live poultry markets are a major source of human H5N1 influenza virus infection in China. J. Virol. 85:13432-13438. PDF

gsgs · Dec 17, 2011

Re: J. Virol. Indications that Live Poultry Markets are a Major Source of Human H5N1 Influenza Virus Infection in China

A/environment/Guizhou/4/2009/01/16
is similar to H5N1 in Laos,2010

multiple reassortments

J. Virol. Indications that Live Poultry Markets are a Major Source of Human H5N1 Influenza Virus Infection in China

Laidback Al

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gsgs

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