Re: China - Mystery disease in 6 provinces - HIV/AIDS ruled out - Various causes suspected including Epstein-Barr virus and reactive arthritis
Re: China - Mystery disease in 6 provinces - HIV/AIDS ruled out - Various causes suspected including Epstein-Barr virus and reactive arthritis
This is a huge find. Lots of information here, including the fact that the doctor in Guangdong with a low CD4 count who claimed to have been infected by a patient was diagnosed with Epstein-Barr and has fully recovered.
Zhong Nanshan is known to many as a hero for his work during the SARS outbreak, but this might be his finest work, IMO.
http://www.zyynb.com/admin/Article_Show.asp?ArticleID=9142
EB virus can be transmitted kissing known as "kissing disease"
时间:2011-05-09 10:13:00 Time :2011-05-09 10:13:00
The afternoon of May 6, Zhong Nanshan, China Academy of Engineering, First Affiliated Hospital of Guangzhou Medical College (hereinafter referred to as Canton Medical a hospital) Conference Room news conference to announce his research team on 60 cases of "suspected AIDS" the latest research results. He said, "negative AIDS" is without basis, half of the patients with mental disorders, of which 80% of people found one or more pathogens, but the disease is known, can be symptomatic treatment.
Zhong Nanshan, urged the public not to discriminate against these people, and recommended to avoid high-risk sexual behavior, greater use of chopsticks, because the human body in such a variety of viruses detected, can be transmitted through sexual contact and saliva.
48 people have extramarital sex
Zhong Nanshan, as early as the beginning of this year, he received many calls and SMS patients, claimed that they suspected infection "negative AIDS", caused the First Affiliated Hospital of Guangzhou Medical College's attention. In the health administrative departments with the support of a set up by Guangzhou Medical Institute of Infectious Diseases, State Key Laboratory of Respiratory Disease virus chambers of special study groups.
Study Group on March 31 this year to May 3 between voluntary testing for a total of 60 officers carried out a systematic clinical observation and pathogen detection, and some relief for the poor people of the testing costs. In these 60 people, 50 people suspected of HIV infection who readme, and another 10 people claiming to be infected family members. This 50 "patients" average 34.2 years old, from 16 provinces, of which 42 males, 8 females, 50 out of 48 person had had extramarital sex.
Common symptoms of their readme fever, rash, skin insect bites flu, skin desquamation, dizziness, headache, tongue long hair, joint swelling, joint ring, etc., history of from 3 months to 10 years, had acute attack, claiming to have contact, communication between the family and colleagues.
Jiangsu experts: commonly known is the "kissing disease"
Zhong Nanshan said "EB" virus, say the words, "an expert in the European population has been called the kissing disease." Ask the Experts reporter that, in fact, "kissing disease" is a common disease. But experts in the mouth of the common diseases, we are not familiar with, and EB virus is even more strange.
What is the "kissing disease"?
Just a gimmick to say
Baidu Encyclopedia of the argument is, "kissing disease" (KissingDisease) is caused by the EB virus infectious disease of acute self-limited, mainly because of close contact such as kissing, sharing food or transmitted by coughing, is common in young people.
Nanjing Drum Tower Hospital ENT compete with director, told reporters that kissing can actually spread disease. If one has a virus kissing, and weak resistance to the other party, then there would have been "kissing disease", causing mouth sores, throat inflammation.
"But as 'kissing disease' can only be considered a little gimmick to say, this world is not exactly a disease called 'kissing disease'." Compete with director, said all transmitted through the saliva of oral diseases can be called the "kissing disease." Through the mouth, saliva has a lot to spread the virus, EB virus is just one of them, hepatitis B virus, Helicobacter pylori, also can be spread through saliva.
What is the kissing disease symptoms?
Do with AIDS, fear of AIDS like disease
"Kissing disease" symptoms are sore throat, fever, cervical lymphadenopathy, such as physical fatigue, disease severity heavier than cold. Fever, sore throat, loss of appetite, fatigue, swollen lymph glands, usually located in the neck, armpit or groin, spleen enlargement, liver enlargement, jaundice, yellow skin, headache, general body pain. The early symptoms of acute HIV infection with symptoms exactly like the period. Caused by psychological factors, and also the "fear of AIDS disease" like symptoms.
These symptoms all point to one fact: low immunity. Kissing disease prevalence is high, it was introduced more than 90% of people have been infected with the disease, but the real incidence of people who did less, because the disease is self-healing.
What is the EB virus?
Closely related with mucosal disease
As strange EB virus, compete with director said, EB virus is a herpes virus, "very" common. Understanding of medical terms from the current, EB virus and associated with mucosal lesions are linked. Such as nasopharyngeal carcinoma and the ED is closely related to the malignant virus. However, ED is still unable to prove that the virus is the only cause of nasopharyngeal carcinoma. In addition to NPC, some gynecological mucosal lesions such as cervicitis, but also closely related with the EB virus. But that does not mean to carry EB virus will be infected.
How common is EB virus in the end?
Our 9-year-olds into a positive 3-5
Nanjing Children's Hospital experts told reporters, EB virus is widespread in the population, according to serological survey of children aged 3 to 5 EB virus vca-lgg antibody positive rate was 90%. But most children had no symptoms of infection, may show mild pharyngitis and upper respiratory tract infection, usually as a cold treatment, but the disease is self-limited disease, without complications, usually 1-2 weeks to will be recovered. However, hospital admissions have also been "body-type EB virus infection" cases, a 12-year-old boy fever 12 days, was as cold treatment. After a CT examination, the child's body found in multiple organ damage. This is a
special case, analysis may be related to the child's own immune system defects.
Why do children infections?
Kiss a child because the parents like
As the name implies, "kissing disease" to infection through kissing, young people should be the most vulnerable people, and Asians than Europeans and Americans more open, and the "kissing disease" a higher incidence. ED caused by the virus in fact the "kissing disease" view, children are also susceptible EB virus. Why? Because many adults like to hold the baby and pro and.
How to prevent "kissing disease"?
Put chopsticks on the table, kiss Do not be frequent
When the oral damage when infected with EB virus, so prevention "kissing disease", we should pay attention to their oral condition. "Because the Chinese people in Europe and America on oral health is not as much attention, so the Chinese people's oral problems may be more common. Compete with Director said that when the bleeding when brushing your teeth, gums, mucosa damage means, we should note that this time, kissing Do not be too frequent. Also note that public food hygiene. "Chinese people are often a large table in a bowl Jian dish, this habit is very bad. Chopsticks or necessary. ? "
33 were found with the EB virus
In more than a month, these personnel receive a comprehensive physical examination. Thematic research group focusing on white blood cells of these officers, plasma, prostatic fluid, vaginal discharge, saliva, paraurethral glands, such as 7 types of urethral swab samples were a total of 258 DNA fluorescent PCR, these tests for Chlamydia trachomatis (CT ), Ureaplasma urealyticum (UU), Neisseria gonorrhoeae (NG), herpes simplex virus (HSV), cytomegalovirus (CMV), EB virus, chronic infection may be formed of 6 or latent infection of pathogens.
After testing, access to the following preliminary results:
First, 60 people have been tested, HIV antibody screening test and white blood cells
Detection of HIV nucleic acid fluorescent PCR were negative.
Second, 60 people have been detected, the total number detected in 48 patients with positive pathogens, accounting for 80%. In this 48-positive pathogens in infected, EB virus-positive were detected in 33, Chlamydia trachomatis (CT) detected a total of 12 were positive for Ureaplasma urealyticum (UU) were detected positive for a total of 9 people, Neisseria gonorrhoeae (NG) were detected positive for a total of 7, cytomegalovirus (CMV) detected a total of 8 positive, herpes simplex virus (HSV) 1 showed positive. Of which 16 were detected in more than 1 pathogen.
Why these subjects who infected more than a number of pathogens? Yesterday afternoon at the "readme suspected diagnosis of HIV infection among Conference", the experts have different views, some people think they are in sexual contact or other close contacts are also infected with a variety of pathogens, but also with a view of their infection with an pathogens after decreased immunity, so as other pathogens are susceptible.
Subjects psychological stress
Zhong Nanshan said, can be seen from these data, they have certainly not AIDS, "HIV negative" argument has no basis, he also not in favor of such a formulation. However, these subjects do have the disease and have formed their problems. These diseases are not only unknown viral infection, but caused by known pathogens. According to test results, Canton Hospital of Infectious Diseases,
part of a hospital personnel were targeted therapy, the symptoms have been alleviated, the public no cause for alarm.
Interestingly, there are 12 people accepted the psychological test, the exception of 7 cases, including suspected disease in 5 cases, one case of anxiety, mild depression in 1. Zhong Nanshan said that the psychological pressure of this group is very large, some people are very afraid. In the first meeting, how some people are afraid to shake hands with him. Where there is a young man to burst into tears at the sight of Zhong Nanshan, said his family is full of guilt, that their dirty sex incriminate his own family.
Zhong Nanshan said that the patients themselves are very painful psychological, medical staff should patiently explain to eliminate the panic, the public not to discriminate against. As to whether these people are "fear of AIDS disease," Zhong Nanshan responded that the reference to foreign countries do have such, but the symptoms of these patients is not caused solely by psychological factors, but there are specific pathogens. These pathogens can be subjected to sexual contact or close contact with infected leukocytes can be in chronic or latent in the presence and impact on human immune function related to form part of the staff to review complaints symptoms, such as reactive arthritis or chronic fatigue syndrome.
Zhong Nanshan said that as the cases are mostly young adults, and there are mostly high-risk sexual behavior prior to the onset, some people describe the symptoms more and pathogen infection, but also did not receive timely, relevant standard treatment, which also suggest that we should try to avoid high-risk sexual behavior , good protection, problems in a timely manner to the formal medical institutions, specialized institutions for treatment. Sexually transmitted diseases are preventable and curable, no need to back the heavy psychological burden.
EB virus can be transmitted kissing
According to reports, the positive detection of pathogens in hospitals are more than 2 / 3 EB virus infection, and a number of family members, while positive, which EB virus infection is often high-fat characteristics. EB virus is no stranger to readers of Guangdong, which is considered closely related to the pathogenesis of NPC, in fact, the virus can also cause infectious mononucleosis syndrome, the disease commonly known as "kissing disease" refers to the EB virus through intimate contact such as kissing, sharing food or cough infection, and cause some symptoms similar to the common cold.
EB virus infection is most acute, but individual cases can become chronic, the clinical manifestations were fever, lymph nodes and other symptoms.
Zhong Nanshan suggested that the public in the family dining out and have to use chopsticks when eating, to avoid cross infection.
Zhong Nanshan team dialogue
Unknown virus not found
Q: Why focus on detection of the 6-related pathogens and sexually transmitted diseases?
A: The main description from the patient's symptoms, suggesting that they should be
chronic, sexually transmitted pathogens, in particular, their symptoms and the "reactive arthritis" is similar to the disease often associated with pathogen infection.
Q: In the past many countries, why not check out the detection of these diseases?
A: First, because the starting point is different from the previously mentioned fear of AIDS patients are mostly "negative AIDS", so the focus is AIDS-related testing; Second, means testing and sampling methods are also different, mainly blood samples detected previously, this sub-sampling, including saliva, genital secretions.
Q: Can you say that they have a STD?
A: You can not be said to be sexually transmitted diseases, first of all these viruses are spread through sexual contact may be, but not the only way to sexual contact; other detection method is the use of nucleic acid fluorescent PCR, this is not a routine test, and some pathogens white blood cells in the subjects to check out, not the genital tract, do not meet health standards for the diagnosis of sexually transmitted diseases.
Q: They are not infected with unknown virus might be?
A: As far as we know, the United States to find a lot of "primer" are not transferred out of the unknown virus. We are the body from these subjects detected
EB virus, and domestic strains of the virus highly homologous, it is not a new virus.
Q: our country have the ability to detect unknown viruses?
A: Our country is the ability to detect, if the concentration of these subjects is a local outbreak, such as SARS have detected the value of these subjects are distributed, there is no need for testing.
Experts say
Will continue to be transmitted
For such test results, subjects are able to accept? Medical conference in a hospital wide infection in liver disease research director Dr Tseng Wen-ting, said he left his own QQ subjects, most people agree that the pathogen was detected, but a few people still worry about actually infected with an unknown virus, leading to decreased immunity, which in turn contracted the virus, few people believe it does not solve their problems.
In the conference site, a number of subjects also came to the scene. Q & A session in the media, a man wearing a blue striped shirt emotional, said Zhong Nanshan, Academician on behalf of the patient to ask questions, "Do we have are not infectious." State Key Laboratory of Respiratory Disease researcher Zhou Rong said,
these subjects are indeed infected by dirty sex, but when they have now become chronic later, to be studied whether there are infectious.
Another interview subjects when asked, for the academician Zhong Nanshan results are satisfactory. The subjects said, "
We can not say satisfaction, Zhong Nanshan, Academician of only gratitude. Helpless in our situation around, he offered for us to test. But if we do not recognize the Ministry of Health patients ill, we may continue to petition on. "
