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J Virol. 2012 Sep 5. [Epub ahead of print]
Evolutionary conservation of the PA-X open reading frame in segment 3 of influenza A virus.
Shi M, Jagger BW, Wise HM, Digard P, Holmes EC, Taubenberger JK.
Source
Center for Infectious Disease Dynamics, Department of Biology, The Pennsylvania State University, University Park, PA 16802, USA.
Abstract
PA-X is a fusion protein of influenza A virus encoded in part from a +1 frameshifted 'X-ORF' in segment 3. We show that the X-ORF of diverse influenza A viruses can be divided into two groups that differ in selection pressure and likely function, reflected in the presence of an internal stop codon and a change in synonymous diversity. Notably, truncated forms of PA-X evolved convergently in swine and dogs, suggesting a strong species-specific effect.
PMID:
22951836
[PubMed - as supplied by publisher]
Evolutionary conservation of the PA-X open reading frame in segment 3 of influenza A virus.
Shi M, Jagger BW, Wise HM, Digard P, Holmes EC, Taubenberger JK.
Source
Center for Infectious Disease Dynamics, Department of Biology, The Pennsylvania State University, University Park, PA 16802, USA.
Abstract
PA-X is a fusion protein of influenza A virus encoded in part from a +1 frameshifted 'X-ORF' in segment 3. We show that the X-ORF of diverse influenza A viruses can be divided into two groups that differ in selection pressure and likely function, reflected in the presence of an internal stop codon and a change in synonymous diversity. Notably, truncated forms of PA-X evolved convergently in swine and dogs, suggesting a strong species-specific effect.
PMID:
22951836
[PubMed - as supplied by publisher]
