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Indoor Air. 2017 Dec 15. doi: 10.1111/ina.12445. [Epub ahead of print]
Routes of transmission of influenza A H1N1, SARS CoV and norovirus in air cabin: Comparative analyses.
Lei H1, Li Y1, Xiao S1, Lin CH2, Norris SL2, Wei D2, Hu Z3, Ji S3.
Author information
Abstract
Identifying the exact transmission route(s) of infectious diseases in indoor environments is a crucial step in developing effective intervention strategies. In this study, we proposed a comparative analysis approach and built a model to simulate outbreaks of three different inflight infections in a similar cabin environment, i.e., influenza A H1N1, severe acute respiratory syndrome (SARS) coronavirus (CoV), and norovirus. The simulation results seemed to suggest that the close contact route was probably the most significant route (contributes 70%, 95% confidence interval (CI): 67%-72%) in the inflight transmission of influenza A H1N1 transmission; as a result, passengers within two rows of the index case had a significantly higher infection risk than others in the outbreak (relative risk (RR): 13.4, 95% CI: 1.5-121.2, P=0.019). For SARS CoV, the airborne, close contact and fomite routes contributed 21% (95% CI: 19%-23%), 29% (95% CI: 27%-31%), and 50% (95% CI: 48%-53%) respectively. For norovirus, the simulation results suggested that the fomite route played the dominant role (contributes 85%, 95% CI: 83%-87%) in most cases; as a result, passengers in aisle seats had a significantly higher infection risk than others (RR: 9.5, 95% CI: 1.2-77.4, P=0.022). This work highlighted a method for using observed outbreak data to analyze the roles of different infection transmission routes. This article is protected by copyright. All rights reserved.
KEYWORDS:
air cabin ; inflight infection ; intervention ; mathematical model ; multi-route transmission ; outbreak
PMID: 29244221 DOI: 10.1111/ina.12445
Routes of transmission of influenza A H1N1, SARS CoV and norovirus in air cabin: Comparative analyses.
Lei H1, Li Y1, Xiao S1, Lin CH2, Norris SL2, Wei D2, Hu Z3, Ji S3.
Author information
Abstract
Identifying the exact transmission route(s) of infectious diseases in indoor environments is a crucial step in developing effective intervention strategies. In this study, we proposed a comparative analysis approach and built a model to simulate outbreaks of three different inflight infections in a similar cabin environment, i.e., influenza A H1N1, severe acute respiratory syndrome (SARS) coronavirus (CoV), and norovirus. The simulation results seemed to suggest that the close contact route was probably the most significant route (contributes 70%, 95% confidence interval (CI): 67%-72%) in the inflight transmission of influenza A H1N1 transmission; as a result, passengers within two rows of the index case had a significantly higher infection risk than others in the outbreak (relative risk (RR): 13.4, 95% CI: 1.5-121.2, P=0.019). For SARS CoV, the airborne, close contact and fomite routes contributed 21% (95% CI: 19%-23%), 29% (95% CI: 27%-31%), and 50% (95% CI: 48%-53%) respectively. For norovirus, the simulation results suggested that the fomite route played the dominant role (contributes 85%, 95% CI: 83%-87%) in most cases; as a result, passengers in aisle seats had a significantly higher infection risk than others (RR: 9.5, 95% CI: 1.2-77.4, P=0.022). This work highlighted a method for using observed outbreak data to analyze the roles of different infection transmission routes. This article is protected by copyright. All rights reserved.
KEYWORDS:
air cabin ; inflight infection ; intervention ; mathematical model ; multi-route transmission ; outbreak
PMID: 29244221 DOI: 10.1111/ina.12445