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Experimental transmission of avian-like swine H1N1 influenza virus between immunologically na?ve and vaccinated pigs

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  • Experimental transmission of avian-like swine H1N1 influenza virus between immunologically na?ve and vaccinated pigs

    Influenza Other Respi Viruses. 2011 Mar 31. doi: 10.1111/j.1750-2659.2011.00233.x. [Epub ahead of print]
    Experimental transmission of avian-like swine H1N1 influenza virus between immunologically na?ve and vaccinated pigs.
    Lloyd LE, Jonczyk M, Jervis CM, Flack DJ, Lyall J, Foote A, Mumford JA, Brown IH, Wood JL, Elton DM.
    Source

    Animal Health Trust, Kentford, Newmarket, Suffolk, UK. Cambridge Infectious Diseases Consortium, Department of Veterinary Medicine, Cambridge, UK. Veterinary Laboratories Agency, Weybridge, New Haw, Addlestone, Surrey, UK.
    Abstract

    Please cite this paper as: Lloyd et al. (2011) Experimental transmission of avian-like swine H1N1 influenza virus between immunologically na?ve and vaccinated pigs. Influenza and Other Respiratory Viruses DOI: 10.1111/j.1750-2659.2011.00233.x. Background  Infection of pigs with swine influenza has been studied experimentally and in the field; however, little information is available on the natural transmission of this virus in pigs. Two studies in an experimental transmission model are presented here, one in immunologically na?ve and one in a combination of vaccinated and na?ve pigs. Objectives  To investigate the transmission of a recent 'avian-like' swine H1N1 influenza virus in naive piglets, to assess the antibody response to a commercially available vaccine and to determine the efficiency of transmission in pigs after vaccination. Methods  Transmission chains were initiated by intranasal challenge of two immunologically na?ve pigs. Animals were monitored daily for clinical signs and virus shedding. Pairs of pigs were sequentially co-housed, and once virus was detected in recipients, prior donors were removed. In the vaccination study, piglets were vaccinated and circulating antibody levels were monitored by haemagglutination inhibition assay. To study transmission in vaccinates, a pair of infected immunologically na?ve animals was co-housed with vaccinated recipient pigs and further pairs of vaccinates were added sequentially as above. The chain was completed by the addition of naive pigs. Results and conclusions  Transmission of the H1N1 virus was achieved through a chain of six pairs of na?ve piglets and through four pairs of vaccinated animals. Transmission occurred with minimal clinical signs and, in vaccinates, at antibody levels higher than previously reported to protect against infection.

    ? 2011 Blackwell Publishing Ltd.

    PMID:
    21668691
    [PubMed - as supplied by publisher]

    http://www.ncbi.nlm.nih.gov/pubmed/21668691
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