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Small Variations Between Species/Subtypes Attributed to Reassortment Evidenced from Polymerase Basic Protein 1 with Other Seven Proteins from Influenza A Virus

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  • Small Variations Between Species/Subtypes Attributed to Reassortment Evidenced from Polymerase Basic Protein 1 with Other Seven Proteins from Influenza A Virus

    Transbound Emerg Dis. 2012 Mar 30. doi: 10.1111/j.1865-1682.2012.01323.x. [Epub ahead of print]
    Small Variations Between Species/Subtypes Attributed to Reassortment Evidenced from Polymerase Basic Protein 1 with Other Seven Proteins from Influenza A Virus.
    Yan S, Wu G.
    Source

     State Key Laboratory of Non-food Biomass Enzyme Technology, National Engineering Research Center for Non-food Biorefinery, Guangxi Key Laboratory of Biorefinery, Guangxi Academy of Sciences, Nanning, China  DreamSciTech Consulting, Shenzhen, China.
    Abstract

    This is a continuation of our studies previously published in this journal to use data analysis to explore why the reassortment of genetic segments from different host species and from different subtypes of influenza A viruses occurred frequently, which was considered the main reason for the generation of new strains. Of eleven proteins from influenza A virus, we have studied seven proteins in our previous studies. To get a full picture, 2352 polymerase basic proteins 1 from influenza A viruses were analysed. The results showed that the variations between host species/subtypes are smaller than those within host species/subtype. In combination with the results obtained from hemagglutinin, neuraminidase, nucleoprotein, matrix proteins 1 and 2, polymerase acidic protein and polymerase basic proteins 1 and 2, the results suggested that the predisposition to reassortment of genetic segments of influenza A virus from different host species and subtypes was mainly because of the small variations between the virus isolates.

    ? 2012 Blackwell Verlag GmbH.

    PMID:
    22462488
    [PubMed - as supplied by publisher]

    This is a continuation of our studies previously published in this journal to use data analysis to explore why the reassortment of genetic segments from different host species and from different subtypes of influenza A viruses occurred frequently, which was considered the main reason for the generat …
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