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Stimulating immune function: A neglected resource against pandemic influenza

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  • Stimulating immune function: A neglected resource against pandemic influenza

    via email -


    STIMULATING IMMUNE FUNCTION: A NEGLECTED RESOURCE AGAINST PANDEMIC INFLUENZA

    Society is rapidly losing its battle against emerging and reemerging infections. HIV continues to inflict considerable human and economic damage, and HINI is causing death, overwhelming health services, and threatening to intensify in the fall with a more virulent strain. The tuberculosis bacillus shows signs of resisting conventional treatment, as does the malaria parasite. Influenza, the agents of food poisoning, methicillin- resistant staphylococcus aureus (MSRA), and hospital- acquired infections (HAIs) take their gloomy toll. Global warming may enlarge the domains of the malaria parasite and other pathogens.

    Stimulating immune function would transform the prevention, treatment, research and economics of infectious disorders. Immunostimulation is propagandized as unavailable, but as early as nineteen eighty-one, published evidence showed that lithium and antidepressants have clinically relevant, immunostimulating and antimicrobial properties. Lithium and antidepressants have been overlooked as immunostimulants, chiefly because they promise to save a fortune, rather than create one.

    Antidepressants can remit tuberculosis, canker sores, cold sores, genital herpes, upper respiratory tract infections, and plantar warts. They can destroy the organisms of various parasitic diseases, including malaria, and are lethal to disease causing fungi and bacteria. Remission of such manifestations of viral infections as sinusitis, bronchitis, frequent colds, sore throats, cold sores and genital herpes in patients taking lithium has been reported. Lithium and antidepressants can reduce the rates of common, ?flu-like? colds, and lithium is capable of preventing recurrences of staphylococcal and streptococcal skin infections.*

    Developing a vaccine for viruses has the disadvantage of having to know the strain, especially a virus such as the human immunodeficiency virus that is known to be rapidly mutating. That problem does not apply to immunostimulants: once stimulated, an immune system is likely to be effective against all strains. One cannot say whether lithium or antidepressants are best suited to HINI, until clinical responses are observed. If not adapted to pandemic preparedness, a disaster may yet befall us. In the 28 years that immunostimulation has been available, vested interests have suppressed it. Among them, government and private laboratories have tried to replicate it using other methods, but they have failed, and are unlikely to succeed.


    * Lieb,J."The immunostimulating and antimicrobial properties of lithium and antidepressants." J Infection (2004) 49 88-93. The eighth of nine reviews published since 1981.

    Julian Lieb, M.D is a medical researcher, specializing in the immunopharmacology of infectious disorders and cancer. He has authored or coauthored forty-five articles and nine books.

  • #2
    Re: Stimulating immune function: A neglected resource against pandemic influenza

    Originally posted by Florida1 View Post
    via email -


    STIMULATING IMMUNE FUNCTION: A NEGLECTED RESOURCE AGAINST PANDEMIC INFLUENZA
    Developing a vaccine for viruses has the disadvantage of having to know the strain, especially a virus such as the human immunodeficiency virus that is known to be rapidly mutating. That problem does not apply to immunostimulants: once stimulated, an immune system is likely to be effective against all strains. One cannot say whether lithium or antidepressants are best suited to HINI, until clinical responses are observed. If not adapted to pandemic preparedness, a disaster may yet befall us. In the 28 years that immunostimulation has been available, vested interests have suppressed it. Among them, government and private laboratories have tried to replicate it using other methods, but they have failed, and are unlikely to succeed.
    Did your correspondent happen to mention which antidepressants? Or is this a phenomenon common to all of them?

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    • #3
      Re: Stimulating immune function: A neglected resource against pandemic influenza

      No. This is the entire email. It was from the author of the paper.

      Comment


      • #4
        Re: Stimulating immune function: A neglected resource against pandemic influenza

        I've always thought Prozac should be in the water - now I know it's so!

        Seriously, I'd love to know which antidepressants in particular the author is referring to - and I also have a question. The article does seem to encompass all manner of infectious processes, but in regard pandemic illnesses like H1N1 - is it not the healthy immune response that is a contributor to the deaths of young, otherwise healthy people?

        Which are better prepared? Those WITH a fortified immune system, or those who aren't quite as strong? I'm always so torn about what to do for myself. Thus far, I've opted for immune "enhancement" ;-)

        Comment


        • #5
          Re: Stimulating immune function: A neglected resource against pandemic influenza

          This is very interesting. I haven't found out anything specific about the AD's, but from these two links:

          Defeating Infectious Disorders by Stimulating Immune Function

          The immunostimulating and antimicrobial properties of lithium and antidepressants
          Auteur(s) / Author(s)
          LIEB Julian ;
          R?sum? / Abstract
          Eicosanoids are products of arachidonic acid (AA), an essential fatty acid. They include prostaglandins (PGs), prostacyclin (PG12), thromboxanes (TXs), leukotrienes (LTs) and hydroxy fatty acids. AA is derived enzymatically from membrane phospholipids and to a lesser extent the diet. Eicosanoids self-regulate every cell, including those synthesizing serotonin, norepinephrine and dopamine and those subserving immune function, such asT-cells, B-cells, natural killer cells, macrophages, monocytes and dendritic cells. There is objective evidence that prostaglandins regulate the physiology of the hypothalamic-pituitary-adrenal axis (HPA). Elucidation of the structure and metabolic pathways of eicosanoids galvanized researchers into illuminating their role in physiology, pathology and pharmacology. Striking contradictions arose: eicosanoids were shown to activate and suppress microorganisms, potentiate and suppress immunity and possess pro- and anticancer properties. As prostaglandins are the most heavily studied eicosanoids in the context of mood and immunity I will focus on them in this article. I will present evidence of the immunostimulating and antimicrobial properties of lithium and antidepressants and propose that these properties are linked to the antiprostaglandin actions of these compounds.
          Revue / Journal Title
          The Journal of infection ISSN 0163-4453 CODEN JINFD2
          Source / Source
          2004, vol. 49, no2, pp. 88-93 [6 page(s) (article)] (102 ref.)


          It looks like inhibition of excess prostaglandins is the mechanism. If there were a way to do that safely, it seems like it would be a good thing when you consider the link between some prostaglandins and inflammation.

          I think I've read about dietary ways of doing that, and some research indicates that fish oil has that benefit:

          Anti-inflammatory Effects Of Omega 3 Fatty Acid In Fish Oil Linked To Lowering Of Prostaglandin

          I think there's a thread on the forum about anti-inflammatory treatment for the flu. I wish there were more research into this.
          _____________________________________________

          Ask Congress to Investigate COVID Origins and Government Response to Pandemic.

          i love myself. the quietest. simplest. most powerful. revolution ever. ---- nayyirah waheed

          "...there’s an obvious contest that’s happening between different sectors of the colonial ruling class in this country. And they would, if they could, lump us into their beef, their struggle." ---- Omali Yeshitela, African People’s Socialist Party

          (My posts are not intended as advice or professional assessments of any kind.)
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