Nature Med. Lethal H5N1 influenza viruses are not resistant to interferon action in human, simian, porcine or chicken cells

[Giuseppe]

[Source: Nature Medicine, full text: (LINK). Extract.]

Lethal H5N1 influenza viruses are not resistant to interferon action in human, simian, porcine or chicken cells

John M Ngunjiri,<SUP>1 </SUP>Kareem N Mohni,<SUP>1, 3 </SUP>Margaret J Sekellick,<SUP>1 </SUP>Stacey Schultz-Cherry,<SUP>2 </SUP>Robert G Webster<SUP>2 </SUP>& Philip I Marcus<SUP>1</SUP>
Journal name: Nature Medicine / Volume: 18, Pages: 1456?1457 / Year published: (2012) / DOI: doi:10.1038/nm.2879

Published online 05 October 2012
<INS>

• Addendum (October, 2012)

</INS>
To the Editor:

Seo et al.<SUP>1</SUP> reported that highly virulent H5N1 influenza viruses were virtually totally resistant to the action of interferon-α (IFN-α), IFN-γ or tumor necrosis factor-α (TNF-α), as tested in St. Jude porcine lung (SJPL) cells. Furthermore, they concluded that the NS1 protein of these highly pathogenic viruses conferred?

(...)


GenBank/EMBL/DDBJ

• JX120148
• JX120149
• JX120150

Affiliations

1. Virus and Interferon Research Laboratory, Department of Molecular and Cell Biology, University of Connecticut, Storrs, Connecticut, USA.
   • John M Ngunjiri,
   • Kareem N Mohni,
   • Margaret J Sekellick &
   • Philip I Marcus
2. Division of Virology, Department of Infectious Diseases, St. Jude Children's Research Hospital, Memphis, Tennessee, USA.
   • Stacey Schultz-Cherry &
   • Robert G Webster
3. Current address: Department of Molecular, Microbial and Structural Biology, University of Connecticut Health Center, Farmington, Connecticut, USA.
   • Kareem N Mohni

Correspondence to:

• Philip I Marcus

-
------