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Experimental Approaches to Identify Host Factors Important for Influenza Virus

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  • Experimental Approaches to Identify Host Factors Important for Influenza Virus


    Cold Spring Harb Perspect Med. 2019 Dec 23. pii: a038521. doi: 10.1101/cshperspect.a038521. [Epub ahead of print] Experimental Approaches to Identify Host Factors Important for Influenza Virus.

    Schaack GA1, Mehle A1.
    Author information

    1 Department of Medical Microbiology and Immunology, University of Wisconsin Madison, Madison, Wisconsin 53706, USA.

    Abstract

    An ever-expanding toolkit of experimental methods provides the means to discover and characterize host factors important for influenza virus. Here, we describe common methods for investigating genetic relationships and physical interactions between virus and host. A comprehensive knowledge of host:virus interactions is key to understanding how influenza virus exploits the host cell and to potentially identify vulnerabilities that may be manipulated to prevent or treat disease.
    Copyright ? 2019 Cold Spring Harbor Laboratory Press; all rights reserved.


    PMID: 31871241 DOI: 10.1101/cshperspect.a038521


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