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Int J Mol Sci. 2017 Aug 1;18(8). pii: E1673. doi: 10.3390/ijms18081673.
Influenza A Virus-Host Protein Interactions Control Viral Pathogenesis.
Zhao M1, Wang L2, Li S3.
Author information
Abstract
The influenza A virus (IAV), a member of the Orthomyxoviridae family, is a highly transmissible respiratory pathogen and represents a continued threat to global health with considerable economic and social impact. IAV is a zoonotic virus that comprises a plethora of strains with different pathogenic profiles. The different outcomes of viral pathogenesis are dependent on the engagement between the virus and the host cellular protein interaction network. The interactions may facilitate virus hijacking of host molecular machinery to fulfill the viral life cycle or trigger host immune defense to eliminate the virus. In recent years, much effort has been made to discover the virus-host protein interactions and understand the underlying mechanisms. In this paper, we review the recent advances in our understanding of IAV-host interactions and how these interactions contribute to host defense and viral pathogenesis.
KEYWORDS:
flu; host defense; protein interactome; virulence; virus?host interactions
PMID: 28763020 DOI: 10.3390/ijms18081673
Free full text
Influenza A Virus-Host Protein Interactions Control Viral Pathogenesis.
Zhao M1, Wang L2, Li S3.
Author information
Abstract
The influenza A virus (IAV), a member of the Orthomyxoviridae family, is a highly transmissible respiratory pathogen and represents a continued threat to global health with considerable economic and social impact. IAV is a zoonotic virus that comprises a plethora of strains with different pathogenic profiles. The different outcomes of viral pathogenesis are dependent on the engagement between the virus and the host cellular protein interaction network. The interactions may facilitate virus hijacking of host molecular machinery to fulfill the viral life cycle or trigger host immune defense to eliminate the virus. In recent years, much effort has been made to discover the virus-host protein interactions and understand the underlying mechanisms. In this paper, we review the recent advances in our understanding of IAV-host interactions and how these interactions contribute to host defense and viral pathogenesis.
KEYWORDS:
flu; host defense; protein interactome; virulence; virus?host interactions
PMID: 28763020 DOI: 10.3390/ijms18081673
Free full text