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Altered splenic miRNA expression profile in H1N1 swine influenza

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  • Altered splenic miRNA expression profile in H1N1 swine influenza

    Arch Virol. 2015 Feb 6. [Epub ahead of print]
    Altered splenic miRNA expression profile in H1N1 swine influenza.

    Huang L1, Ma J, Sun Y, Lv Y, Lin W, Liu M, Tu C, Zhou P, Gu W, Su S, Zhang G.
    Author information

    Abstract

    Previous studies have demonstrated the key regulatory roles played by microRNAs (miRNAs) in influenza virus-host interactions. To gain more insight into the contribution of miRNAs to the host immune response, spleen tissues from mice infected with A/Swine/GD/2/12 (H1N1) virus were harvested 5 days postinfection, and miRNA deep sequencing was performed. The results showed that 50 miRNAs were modulated. Interestingly, pathway analysis of miRNAs and targets showed that upregulated miR-124-3p interacts with innate immune-related pathways such as the Toll-like receptor pathway, RIG-I-like receptor signaling pathway, NOD-like receptor signaling pathway and JAK-STAT signaling pathway, and this might play a major role in the anti-inflammatory response. Further understanding of the roles played by these miRNAs in influenza virus infection will provide new insights into host-pathogen interactions.


    PMID: 25655261 [PubMed - as supplied by publisher]
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