Two adult patients with acute necrotizing encephalopathy following influenza virus infection

[tetano]

Rinsho Shinkeigaku. 2020 Jan 19. doi: 10.5692/clinicalneurol.cn-001381. [Epub ahead of print] [Two adult patients with acute necrotizing encephalopathy following influenza virus infection].

[Article in Japanese]

Iizuka K¹, Suzuki K¹, Shiina T¹, Nakamura T², Funakoshi K¹, Hirata K¹.
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Abstract

Influenza encephalopathy is characterized by high fever, disturbance of consciousness following influenza virus infection. We encountered 2 adult patients with influenza-associated acute necrotizing encephalopathy (Case 1, a 70-year-old woman with diabetes; Case 2, a 49-year-old woman with multiple myeloma), showing hemorrhagic lesions in the bilateral thalamus. Case 1 presented with fever and disturbance of consciousness followed by status epilepticus, and Case 2 developed fever and drowsiness as initial manifestation. Influenza type A was positive in Case 1 and influenza type B was positive in Case 2. In the acute phase, 2 patients required respiratory ventilation and were treated with anti-influenza drug, steroid and immunoglobulin. Cognitive impairment remained in the both patients in the chronic phase. When acute necrotizing encephalopathy is suspected, intensive treatment should be started as early as possible to improve clinical outcome of patients.


KEYWORDS:

acute necrotizing encephalopathy; adult patients; influenza virus infection

PMID: 31956199 DOI: 10.5692/clinicalneurol.cn-001381