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Respiratory Viral Infections in Infants with Possible Sepsis

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  • Respiratory Viral Infections in Infants with Possible Sepsis

    J Med Virol. 2018 Sep 7. doi: 10.1002/jmv.25309. [Epub ahead of print]
    Respiratory Viral Infections in Infants with Possible Sepsis.

    Aykac K1, Oncel EK1, Basaranoglu ST1, Alp A2, Cengiz AB1, Ceyhan M1, Kara A1.
    Author information

    Abstract

    BACKGROUND:

    Knowledge of infections leading sepsis is needed to develop comprehensive infection prevention and sepsis early recognition and treatment strategies.The aim of this study was to investigate the etiology of sepsis and evaluate the proportion of respiratory viral pathogens in infants under two years of age with possible sepsis.
    METHODS:

    The prospective study was performed in two years. Multiplex RT-PCR was performed to detect viral pathogens. All patients who were included in this study had sepsis symptoms as defined by the Surviving Sepsis Campaign.
    RESULTS:

    We compared 90 patients with sepsis into three groups as patients (n=33) had only viral positivity in nasopharyngeal swab and patients (17) had proven bacterial infection with or without viral infection and patients (40) without pathogen detection. Human rhinovirus (16.7%) and influenza (7.8%) were the most commonly seen viruses. Cough was more common in viral infection group than other groups (p=0.02) and median thrombocyte count was lower in bacterial infection group than the others (p=0.01). Patients had bacterial sepsis had the longest duration of hospitalization than the other groups (p=0.04). In winter and spring patients with sepsis mostly had viral infection however in summer and autumn patients were mostly that we could not prove an infection agents (p=0.02).
    CONCLUSIONS:

    Our results suggest that respiratory tract viruses may play an important role in patients with sepsis and they should be kept in mind especially in winter and spring seasons. With an overall viral respiratory viruses as a single pathogen detection rate of 36.6% in sepsis etiology. This article is protected by copyright. All rights reserved.
    This article is protected by copyright. All rights reserved.


    KEYWORDS:

    Sepsis; infant; respiratory viruses

    PMID: 30192397 DOI: 10.1002/jmv.25309
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