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Association of day 4 cumulative fluid balance with mortality in critically ill patients with influenza: A multicenter retrospective cohort study in Taiwan

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  • Association of day 4 cumulative fluid balance with mortality in critically ill patients with influenza: A multicenter retrospective cohort study in Taiwan

    PLoS One. 2018 Jan 9;13(1):e0190952. doi: 10.1371/journal.pone.0190952. eCollection 2018.
    Association of day 4 cumulative fluid balance with mortality in critically ill patients with influenza: A multicenter retrospective cohort study in Taiwan.

    Chao WC1,2,3, Tseng CH1,4,5, Chien YC6, Sheu CC7,8, Tsai MJ7,8, Fang WF9,10, Chen YM9, Kao KC11,12, Hu HC11,12, Perng WC13, Yang KY14,15, Chen WC14,15, Liang SJ16, Wu CL1,17,18, Wang HC6, Chan MC1,19; TSIRC (Taiwan Severe Influenza Research Consortium).
    Author information

    Abstract

    BACKGROUND:

    Fluid balance is a fundamental management of patients with sepsis, and this study aimed to investigate the impact of cumulative fluid balance on critically ill patients with influenza admitted to an intensive care unit (ICU).
    METHODS:

    This multicenter retrospective cohort study was conducted by the Taiwan Severe Influenza Research Consortium (TSIRC) which includes eight medical centers. Patients with virology-proven influenza infection admitted to ICUs between October 2015 and March 2016 were included for analysis.
    RESULTS:

    A total of 296 patients were enrolled (mean age: 61.415.6 years; 62.8% men), and 92.2% (273/296) of them required mechanical ventilation. In the survivors, the daily fluid balance was positive from day 1 to day 3, and then gradually became negative from day 4 to day 7, whereas daily fluid balance was continuously positive in the non-survivors. Using the cumulative fluid balance from day 1-4 as a cut-off point, we found that a negative cumulative day 1-4 fluid balance was associated with a lower 30-day mortality rate (log-rank test, P = 0.003). To evaluate the impact of shock on this association, we divided the patients into shock and non-shock groups. The positive correlation between negative day 1-4 fluid balance and mortality was significant in the non-shock group (log-rank test, P = 0.008), but not in the shock group (log-rank test, P = 0.396). In a multivariate Cox proportional hazard regression model adjusted for age, sex, cerebrovascular disease, and PaO2/FiO2, day 1-4 fluid balance was independently associated with a higher 30-day mortality rate (aHR 1.088, 95% CI: 1.007-1.174).
    CONCLUSIONS:

    A negative day 1-4 cumulative fluid balance was associated with a lower mortality rate in critically ill patients with influenza. Our findings indicate the critical role of conservative fluid strategy in the management of patients with complicated influenza.


    PMID: 29315320 DOI: 10.1371/journal.pone.0190952
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