BMC Nephrol. 2017 Mar 20;18(1):96. doi: 10.1186/s12882-017-0512-y.
Case report - atypical hemolytic uremic syndrome triggered by influenza B.
Kobbe R1, Schild R2, Christner M2, Oh J2, Loos S2, Kemper MJ2.
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Abstract
BACKGROUND:
Influenza A infections have been described to cause secondary hemolytic uremic syndrome and to trigger atypical hemolytic uremic syndrome (aHUS) in individuals with an underlying genetic complement dysregulation. To date, influenza B has not been reported to trigger aHUS.
CASE PRESENTATION:
A 6-month-old boy presented with hemolytic uremic syndrome triggered by influenza B infection. Initially the child recovered spontaneously. When he relapsed Eculizumab treatment was initiated, resulting in complete and sustained remission. A pathogenic mutation in membrane cofactor protein (MCP) was detected.
CONCLUSION:
Influenza B is a trigger for aHUS and might be underreported as such. Influenza vaccination may protect patients at risk.
KEYWORDS:
Atypical HUS; HUS; Hemolytic uremic syndrome; Influenza; Influenza vaccination; Quadrivalent; aHUS
PMID: 28320387 PMCID: PMC5358041 DOI: 10.1186/s12882-017-0512-y
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Case report - atypical hemolytic uremic syndrome triggered by influenza B.
Kobbe R1, Schild R2, Christner M2, Oh J2, Loos S2, Kemper MJ2.
Author information
Abstract
BACKGROUND:
Influenza A infections have been described to cause secondary hemolytic uremic syndrome and to trigger atypical hemolytic uremic syndrome (aHUS) in individuals with an underlying genetic complement dysregulation. To date, influenza B has not been reported to trigger aHUS.
CASE PRESENTATION:
A 6-month-old boy presented with hemolytic uremic syndrome triggered by influenza B infection. Initially the child recovered spontaneously. When he relapsed Eculizumab treatment was initiated, resulting in complete and sustained remission. A pathogenic mutation in membrane cofactor protein (MCP) was detected.
CONCLUSION:
Influenza B is a trigger for aHUS and might be underreported as such. Influenza vaccination may protect patients at risk.
KEYWORDS:
Atypical HUS; HUS; Hemolytic uremic syndrome; Influenza; Influenza vaccination; Quadrivalent; aHUS
PMID: 28320387 PMCID: PMC5358041 DOI: 10.1186/s12882-017-0512-y
Free full text