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New Microbes New Infect. 2016 May 26;13:17-21. doi: 10.1016/j.nmni.2016.05.011. eCollection 2016.
Emerging ST121/agr4 community-associated methicillin-resistant Staphylococcus aureus (MRSA) with strong adhesin and cytolytic activities: trigger for MRSA pneumonia and fatal aspiration pneumonia in an influenza-infected elderly.
Wan TW1, Tomita Y2, Saita N3, Konno K3, Iwao Y4, **** WC5, Teng LJ6, Yamamoto T4.
Author information
Abstract
The pathogenesis of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) pneumonia in influenza-infected elderly individuals has not yet been elucidated in detail. In the present study, a 92-year-old man infected with influenza developed CA-MRSA pneumonia. His CA-MRSA was an emerging type, originated in ST121/agr4 S. aureus, with diversities of Panton-Valentine leucocidin (PVL)(-)/spat5110/SCCmecV(+) versus PVL(+)/spat159((etc.))/SCCmec (-), but with common virulence potentials of strong adhesin and cytolytic activities. Resistance to erythromycin/clindamycin (inducible-type) and gentamicin was detected. Pneumonia improved with the administration of levofloxacin, but with the subsequent development of fatal aspiration pneumonia. Hence, characteristic CA-MRSA with strong adhesin and cytolytic activities triggered influenza-related sequential complications.
KEYWORDS:
Community-associated methicillin-resistant Staphylococcus aureus; ST121/agr4 lineage; elderly community-acquired pneumonia; fatal aspiration pneumonia; influenza
PMID: 27358743 DOI: 10.1016/j.nmni.2016.05.011
[PubMed] Free full text
Emerging ST121/agr4 community-associated methicillin-resistant Staphylococcus aureus (MRSA) with strong adhesin and cytolytic activities: trigger for MRSA pneumonia and fatal aspiration pneumonia in an influenza-infected elderly.
Wan TW1, Tomita Y2, Saita N3, Konno K3, Iwao Y4, **** WC5, Teng LJ6, Yamamoto T4.
Author information
Abstract
The pathogenesis of community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) pneumonia in influenza-infected elderly individuals has not yet been elucidated in detail. In the present study, a 92-year-old man infected with influenza developed CA-MRSA pneumonia. His CA-MRSA was an emerging type, originated in ST121/agr4 S. aureus, with diversities of Panton-Valentine leucocidin (PVL)(-)/spat5110/SCCmecV(+) versus PVL(+)/spat159((etc.))/SCCmec (-), but with common virulence potentials of strong adhesin and cytolytic activities. Resistance to erythromycin/clindamycin (inducible-type) and gentamicin was detected. Pneumonia improved with the administration of levofloxacin, but with the subsequent development of fatal aspiration pneumonia. Hence, characteristic CA-MRSA with strong adhesin and cytolytic activities triggered influenza-related sequential complications.
KEYWORDS:
Community-associated methicillin-resistant Staphylococcus aureus; ST121/agr4 lineage; elderly community-acquired pneumonia; fatal aspiration pneumonia; influenza
PMID: 27358743 DOI: 10.1016/j.nmni.2016.05.011
[PubMed] Free full text