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Neutrophils May Be a Vehicle for Viral Replication and Dissemination in Human H5N1 Avian Influenza [Chicago Journals - Clinical Infectious Diseases]
Clinical Infectious Diseases 2008;47:000?000
? 2008 by the Infectious Diseases Society of America. All rights reserved.
1058-4838/2008/4712-00XX$15.00
DOI: 10.1086/593196
BRIEF REPORT
Neutrophils May Be a Vehicle for Viral Replication and Dissemination in Human H5N1 Avian Influenza
Yingying Zhao,1 Min Lu,1 Lok Ting Lau,2,3,4 Jie Lu,2,3,4 Zifen Gao,1 Jinhua Liu,5 Albert Cheung Hoi Yu,2,3 Qi Cao,1 Juxiang Ye,1 Michael A. McNutt,1 and Jiang Gu1,2,6
1Department of Pathology, School of Basic Medical Sciences,
2Infectious Disease Center, and
3Neuroscience Research Institute, Peking University,
4Hai Kang Life Corporation Limited, and
5College of Veterinary Medicine, China Agricultural University, Beijing, China; and
6Department of Pathology, State University of New York, Health Science Center at Brooklyn, Brooklyn
The mechanism of systemic spread of H5N1 virus in patients with avian influenza is unknown. Here, H5N1 nucleoprotein and hemagglutinin were identified by immunohistochemistry in the nucleus and cytoplasm of neutrophils in the placental blood of a pregnant woman. Viral RNA was detected in neutrophils by in situ hybridization and enhanced real-time polymerase chain reaction. Therefore, neutrophils may serve as a vehicle for viral replication and transportation in avian influenza.
Received 21 May 2008; accepted 29 August 2008; electronically published 6 November 2008.
Reprints or correspondence: Dr. Jiang Gu, Dept. of Pathology, School of Basic Medical Sciences, Peking (Beijing) University, 38 Xueyan Rd., Beijing, China 100083 (jianggu@bjmu.edu.cn).
* aY.Z. and M.L. share equal responsibility as first author.
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<cite cite="http://www.journals.uchicago.edu/doi/abs/10.1086/593196">Chicago Journals - Clinical Infectious Diseases</cite>
? 2008 by the Infectious Diseases Society of America. All rights reserved.
1058-4838/2008/4712-00XX$15.00
DOI: 10.1086/593196
BRIEF REPORT
Neutrophils May Be a Vehicle for Viral Replication and Dissemination in Human H5N1 Avian Influenza
Yingying Zhao,1 Min Lu,1 Lok Ting Lau,2,3,4 Jie Lu,2,3,4 Zifen Gao,1 Jinhua Liu,5 Albert Cheung Hoi Yu,2,3 Qi Cao,1 Juxiang Ye,1 Michael A. McNutt,1 and Jiang Gu1,2,6
1Department of Pathology, School of Basic Medical Sciences,
2Infectious Disease Center, and
3Neuroscience Research Institute, Peking University,
4Hai Kang Life Corporation Limited, and
5College of Veterinary Medicine, China Agricultural University, Beijing, China; and
6Department of Pathology, State University of New York, Health Science Center at Brooklyn, Brooklyn
The mechanism of systemic spread of H5N1 virus in patients with avian influenza is unknown. Here, H5N1 nucleoprotein and hemagglutinin were identified by immunohistochemistry in the nucleus and cytoplasm of neutrophils in the placental blood of a pregnant woman. Viral RNA was detected in neutrophils by in situ hybridization and enhanced real-time polymerase chain reaction. Therefore, neutrophils may serve as a vehicle for viral replication and transportation in avian influenza.
Received 21 May 2008; accepted 29 August 2008; electronically published 6 November 2008.
Reprints or correspondence: Dr. Jiang Gu, Dept. of Pathology, School of Basic Medical Sciences, Peking (Beijing) University, 38 Xueyan Rd., Beijing, China 100083 (jianggu@bjmu.edu.cn).
* aY.Z. and M.L. share equal responsibility as first author.
-