Int J Infect Dis . Characterization of an Influenza A(H3N2) virus isolated from a case of Lemierre syndrome, encephalitis and uveitis in Italy

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Int J Infect Dis


. 2026 Apr 5:108693.
doi: 10.1016/j.ijid.2026.108693. Online ahead of print.
Characterization of an Influenza A(H3N2) virus isolated from a case of Lemierre syndrome, encephalitis and uveitis in Italy

Antonio Mastroianni ¹ , Sara Piacentini ² , Valeria Vangeli ¹ , Giuliana Guadagnino ¹ , Marzia Facchini ³ , Emanuela Giombini ³ , Giuseppina Di Mario ³ , Concetta Fabiani ³ , Luciana Chidichimo ¹ , Lavinia Berardelli ¹ , Marianna Puzzo ⁴ , Giuseppina Giannico ⁵ , Maria Vittoria Mauro ⁵ , Francesca Greco ⁵ , Paola Stefanelli ³ , Sonia Greco ¹ , Simona Puzelli ³


Affiliations

• PMID: 41946445
• DOI: 10.1016/j.ijid.2026.108693

Abstract

Lemierre's syndrome (LS) is a rare, life-threatening complication of an acute oropharyngeal infection. Here, a rare case of LS due to influenza A(H3N2) infection characterized by venous thrombosis of the jugular vein, concomitant lymphocytic encephalitis and uveitis was described. Moreover, we compared this case with other literature-reported cases with complications due to Lemierre's syndrome.

Keywords: Influenza A virus; Lemierre syndrome; extra-pulmonary complications; molecular characterization.