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J Microbiol Biotechnol. 2019 Jun 4. doi: 10.4014/jmb.1903.03053. [Epub ahead of print]
Structure and function of the influenza A virus non-structural protein 1.
Han CW1, Jeong MS2, Jang SB1.
Author information
Abstract
The influenza A virus is a highly infectious respiratory pathogen and can cause respiratory disease annually. To prevent surges of this virus infection, an understanding of the characteristics of virus-host interaction and development of an anti-viral agent is urgently needed. The influenza A virus can infect mammalian species including humans, pigs, horses and seals. Furthermore, this virus can switch hosts and form a novel lineage. This so-called zoonotic infection provides an opportunity for virus adaptation to the new host and leads to pandemic. Most influenza A viruses express proteins that antagonize the antiviral defense of the host cell. The non-structural protein 1 (NS1) of the influenza A virus is the most important viral regulatory factor controlling cellular processes to modulate host cell gene expression and double-stranded RNA (dsRNA)-mediated antiviral response. This review focuses on the influenza A virus NS1 protein and outlines the current issues including the life cycle of the influenza A virus, structural characterization of the influenza A virus NS1, interaction between NS1 and host immune response factor, and design of inhibitors resistant to the influenza A virus.
KEYWORDS:
Influenza A virus; NS1; antiviral defense; inhibitor; virus-host interaction
PMID: 31154753 DOI: 10.4014/jmb.1903.03053
Free full text
Structure and function of the influenza A virus non-structural protein 1.
Han CW1, Jeong MS2, Jang SB1.
Author information
Abstract
The influenza A virus is a highly infectious respiratory pathogen and can cause respiratory disease annually. To prevent surges of this virus infection, an understanding of the characteristics of virus-host interaction and development of an anti-viral agent is urgently needed. The influenza A virus can infect mammalian species including humans, pigs, horses and seals. Furthermore, this virus can switch hosts and form a novel lineage. This so-called zoonotic infection provides an opportunity for virus adaptation to the new host and leads to pandemic. Most influenza A viruses express proteins that antagonize the antiviral defense of the host cell. The non-structural protein 1 (NS1) of the influenza A virus is the most important viral regulatory factor controlling cellular processes to modulate host cell gene expression and double-stranded RNA (dsRNA)-mediated antiviral response. This review focuses on the influenza A virus NS1 protein and outlines the current issues including the life cycle of the influenza A virus, structural characterization of the influenza A virus NS1, interaction between NS1 and host immune response factor, and design of inhibitors resistant to the influenza A virus.
KEYWORDS:
Influenza A virus; NS1; antiviral defense; inhibitor; virus-host interaction
PMID: 31154753 DOI: 10.4014/jmb.1903.03053
Free full text