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Influenza virus NS1 protein binds cellular DNA to block transcription of antiviral genes

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  • Influenza virus NS1 protein binds cellular DNA to block transcription of antiviral genes

    Biochim Biophys Acta. 2016 Sep 21. pii: S1874-9399(16)30190-0. doi: 10.1016/j.bbagrm.2016.09.005. [Epub ahead of print]
    Influenza virus NS1 protein binds cellular DNA to block transcription of antiviral genes.

    Anastasina M1, Le May N2, Bugai A3, Fu Y4, S?derholm S5, Gaelings L4, Ohman T5, Tynell J6, Kytt?nen S4, Barboric M3, Nyman TA7, Matikainen S3, Julkunen I8, Butcher SJ5, Egly JM9, Kainov DE10.
    Author information

    Abstract

    Influenza NS1 protein is an important virulence factor that is capable of binding double-stranded (ds) RNA and inhibiting dsRNA-mediated host innate immune responses. Here we show that NS1 can also bind cellular dsDNA. This interaction prevents loading of transcriptional machinery to the DNA, thereby attenuating IAV-mediated expression of antiviral genes. Thus, we identified a previously undescribed strategy, by which RNA virus inhibits cellular transcription to escape antiviral response and secure its replication.
    Copyright ? 2016. Published by Elsevier B.V.


    KEYWORDS:

    Antiviral responses; Influenza A virus; Innate immunity; Regulation of gene expression; Viral counter-responses

    PMID: 27664935 DOI: 10.1016/j.bbagrm.2016.09.005
    [PubMed - as supplied by publisher]
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