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The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus and HIV infections

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  • The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus and HIV infections

    Virulence. 2019 Apr 10. [Epub ahead of print]
    The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus and HIV infections.

    Mehrbod P1, Ande SR2, Alizadeh J3,4,5, Rahimizadeh S6, Shariati A3, Malek H7, Hashemi M8, Glover KKM9, Sher AA9, Coombs KM9,10,4, Ghavami S3,4,5,11.
    Author information

    Abstract

    Virus infection induces different cellular responses in infected cells. These include cellular stress responses like autophagy and unfolded protein response (UPR). Both autophagy and UPR are connected to programmed cell death I (apoptosis) in chronic stress conditions to regulate cellular homeostasis via Bcl2 family proteins, CHOP and Beclin-1. In this review article we first briefly discuss arboviruses, influenza virus, and HIV and then describe the concepts of apoptosis, autophagy and UPR. Finally, we focus upon how apoptosis, autophagy and UPR are involved in regulation of cellular responses to arboviruses, influenza virus and HIV infections.


    KEYWORDS:

    Bcl2 family protein; Caspase; Cell Stress; Virus infection host response

    PMID: 30966844
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