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Front Microbiol. 2019 Jan 29;10:39. doi: 10.3389/fmicb.2019.00039. eCollection 2019.
Influenza Virus Neuraminidase Structure and Functions.
McAuley JL1, Gilbertson BP1, Trifkovic S1,2, Brown LE1, McKimm-Breschkin JL1.
Author information
Abstract
With the constant threat of emergence of a novel influenza virus pandemic, there must be continued evaluation of the molecular mechanisms that contribute to virulence. Although the influenza A virus surface glycoprotein neuraminidase (NA) has been studied mainly in the context of its role in viral release from cells, accumulating evidence suggests it plays an important, multifunctional role in virus infection and fitness. This review investigates the various structural features of NA, linking these with functional outcomes in viral replication. The contribution of evolving NA activity to viral attachment, entry and release of virions from infected cells, and maintenance of functional balance with the viral hemagglutinin are also discussed. Greater insight into the role of this important antiviral drug target is warranted.
KEYWORDS:
HA:NA balance; NA; hemagglutinin; infection; influenza; neuraminidase; sialic acid
PMID: 30761095 PMCID: PMC6362415 DOI: 10.3389/fmicb.2019.00039
Free full text
Influenza Virus Neuraminidase Structure and Functions.
McAuley JL1, Gilbertson BP1, Trifkovic S1,2, Brown LE1, McKimm-Breschkin JL1.
Author information
Abstract
With the constant threat of emergence of a novel influenza virus pandemic, there must be continued evaluation of the molecular mechanisms that contribute to virulence. Although the influenza A virus surface glycoprotein neuraminidase (NA) has been studied mainly in the context of its role in viral release from cells, accumulating evidence suggests it plays an important, multifunctional role in virus infection and fitness. This review investigates the various structural features of NA, linking these with functional outcomes in viral replication. The contribution of evolving NA activity to viral attachment, entry and release of virions from infected cells, and maintenance of functional balance with the viral hemagglutinin are also discussed. Greater insight into the role of this important antiviral drug target is warranted.
KEYWORDS:
HA:NA balance; NA; hemagglutinin; infection; influenza; neuraminidase; sialic acid
PMID: 30761095 PMCID: PMC6362415 DOI: 10.3389/fmicb.2019.00039
Free full text