Virology. 2018 Oct 2;525:161-169. doi: 10.1016/j.virol.2018.09.016. [Epub ahead of print]
The avian influenza virus PA segment mediates strain-specific antagonism of BST-2/tetherin.
Narkpuk J1, Jongkaewwattana A1, Teeravechyan S2.
Author information
Abstract
BST-2 is an antiviral protein described as a powerful cross-species transmission barrier for simian immunodeficiency viruses. Influenza viruses appear to interact with BST-2, raising the possibility that BST-2 may be a barrier for cross-species transmission. An MDCK-based cell line expressing human BST-2 was generated to study human-derived A/Puerto Rico/8/36 (H1N1; PR8) as well as two low pathogenic avian influenza viruses (subtypes H4N6 and H6N1). The H4N6 and H6N1 viruses were less affected by BST-2 expression than PR8, due to their ability to decrease BST-2 levels, a function localized to the PA segment of both avian viruses. Experiments with PA-mutant and -chimeric viruses confirmed that the avian PA segment conferred BST-2 downregulation and antagonism. These results indicate a species-specific ability of PA from low pathogenic avian viruses to mitigate human BST-2 antiviral activity, suggesting that BST-2 is unlikely to be a general cross-species barrier to transmission of such viruses to humans.
KEYWORDS:
Avian influenza; BST-2; Influenza virus; NS1; PA; PA-X; Tetherin
PMID: 30290311 DOI: 10.1016/j.virol.2018.09.016
- Do not take medical advice from the internet. If you have any medical questions please consult your medical practitioner.
LATEST POSTS - click HERE
Check out the FAQ,Terms of Service & Disclaimers by clicking the link. Please register to be able to post. By viewing this site you are agreeing to our Terms of Service and Acknowledge our Disclaimers.
FluTrackers.com Inc. does not provide medical advice. Information on this web site is collected from various internet resources, and the FluTrackers board of directors makes no warranty to the safety, efficacy, correctness or completeness of the information posted on this site by any author or poster. The information collated here is for instructional and/or discussion purposes only and is NOT intended to diagnose or treat any disease, illness, or other medical condition. Every individual reader or poster should seek advice from their personal physician/healthcare practitioner before considering or using any interventions that are discussed on this website. By continuing to access this website you agree to consult your personal physican before using any interventions posted on this website, and you agree to hold harmless FluTrackers.com Inc., the board of directors, the members, and all authors and posters for any effects from use of any medication, supplement, vitamin or other substance, device, intervention, etc. mentioned in posts on this website, or other internet venues referenced in posts on this website.- We are not asking for any donations. Do not donate to any entity who says they are raising funds for us.