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Effects of Transmission Bottlenecks on the Diversity of Influenza A Virus

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  • Effects of Transmission Bottlenecks on the Diversity of Influenza A Virus

    Genetics. 2018 Sep 4. pii: genetics.301510.2018. doi: 10.1534/genetics.118.301510. [Epub ahead of print]
    Effects of Transmission Bottlenecks on the Diversity of Influenza A Virus.

    Sigal D1, Reid JNS1, Wahl LM2.
    Author information

    Abstract

    We investigate the fate of de novo mutations that occur during the in-host replication of a pathogenic virus, predicting the probability that such mutations are passed on during disease transmission to a new host. Using influenza A virus as a model organism, we develop a life-history model of the within-host dynamics of the infection, deriving a multitype branching process with a coupled deterministic model to capture the population of available target cells. We quantify the fate of neutral mutations and mutations affecting five life-history traits: clearance, attachment, budding, cell death, and eclipse phase timing. Despite the severity of disease transmission bottlenecks, our results suggest that in a single transmission event, several mutations that appeared de novo in the donor are likely to be transmitted to the recipient. Even in the absence of a selective advantage for these mutations, the sustained growth phase inherent in each disease transmission cycle generates genetic diversity that is not eliminated during the transmission bottleneck.


    KEYWORDS:

    adaptation; disease transmission; influenza; life history; mutation

    PMID: 30181193 DOI: 10.1534/genetics.118.301510
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