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Influenza A M2 transmembrane domain tunes its conformational heterogeneity and structural plasticity in the lipid bilayer by forming loop structures

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  • Influenza A M2 transmembrane domain tunes its conformational heterogeneity and structural plasticity in the lipid bilayer by forming loop structures

    Chem Commun (Camb). 2018 May 23. doi: 10.1039/c8cc01533c. [Epub ahead of print]
    Influenza A M2 transmembrane domain tunes its conformational heterogeneity and structural plasticity in the lipid bilayer by forming loop structures.

    Liu Y1, Tan J1, Zhang J1, Li C1, Luo Y1, Ye S1.
    Author information

    Abstract

    We discovered for the first time that the influenza A virus M2TM tunes its conformational heterogeneity and structural plasticity to respond to environmental cues by undergoing a helix-to-loop transition, resolving controversies regarding the mechanism of proton conduction and plasticity of the M2TM in lipid bilayers.


    PMID: 29789823 DOI: 10.1039/c8cc01533c
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