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Influenza A Virus M2 Protein: Roles from Ingress to Egress

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  • Influenza A Virus M2 Protein: Roles from Ingress to Egress

    Int J Mol Sci. 2017 Dec 7;18(12). pii: E2649. doi: 10.3390/ijms18122649.
    Influenza A Virus M2 Protein: Roles from Ingress to Egress.

    Manzoor R1, Igarashi M2,3, Takada A4,5,6.
    Author information

    Abstract

    Influenza A virus (IAV) matrix protein 2 (M2) is among the smallest bona fide, hence extensively studied, ion channel proteins. The M2 ion channel activity is not only essential for virus replication, but also involved in modulation of cellular homeostasis in a variety of ways. It is also the target for ion channel inhibitors, i.e., anti-influenza drugs. Thus far, several studies have been conducted to elucidate its biophysical characteristics, structure-function relationships of the ion channel, and the M2-host interactome. In this review, we discuss M2 protein synthesis and assembly into an ion channel, its roles in IAV replication, and the pathophysiological impact on the host cell.


    KEYWORDS:

    M2 protein; influenza A virus; pathogenicity

    PMID: 29215568 DOI: 10.3390/ijms18122649
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