Tweet
Clin Microbiol Infect. 2016 Jul 14. pii: S1198-743X(16)30231-2. doi: 10.1016/j.cmi.2016.07.007. [Epub ahead of print]
Functional balance between Neuraminidase and Hemagglutinin in influenza viruses.
Gaymard A1, Le Briand N2, Frobert E3, Lina B4, Escuret V5.
Author information
Abstract
Seasonal Influenza A and B viruses are important human pathogens responsible for significant morbidity and mortality worldwide. In addition, Influenza A zoonotic viruses are a constant pandemic threat. These viruses present two major surface glycoproteins: the hemagglutinin (HA) and the neuraminidase (NA). These two glycoproteins both recognize the sialic-acid and have a complementary activity, the HA binds the sialic acid through its receptor binding site, the NA is a receptor-destroying enzyme that cleaves α2-3 and α2-6-linked sialic acids. Therefore, the functional HA/NA balance is a critical factor for a good viral fitness and plays a major role in overcoming the host barrier and the efficiency of sustained human-to-human transmission. While the two glycoproteins are in constant evolution, the HA/NA balance seems to remain stable in human viruses because an optimal balance is required to maintain good viral fitness. Understanding the evolution of influenza viruses requires an in-depth exploration of the HA/NA balance.
Copyright ? 2016 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
KEYWORDS:
HA/NA balance; Hemagglutinin; Influenza viruses; Neuraminidase
PMID: 27424943 DOI: 10.1016/j.cmi.2016.07.007
[PubMed - as supplied by publisher]
Functional balance between Neuraminidase and Hemagglutinin in influenza viruses.
Gaymard A1, Le Briand N2, Frobert E3, Lina B4, Escuret V5.
Author information
Abstract
Seasonal Influenza A and B viruses are important human pathogens responsible for significant morbidity and mortality worldwide. In addition, Influenza A zoonotic viruses are a constant pandemic threat. These viruses present two major surface glycoproteins: the hemagglutinin (HA) and the neuraminidase (NA). These two glycoproteins both recognize the sialic-acid and have a complementary activity, the HA binds the sialic acid through its receptor binding site, the NA is a receptor-destroying enzyme that cleaves α2-3 and α2-6-linked sialic acids. Therefore, the functional HA/NA balance is a critical factor for a good viral fitness and plays a major role in overcoming the host barrier and the efficiency of sustained human-to-human transmission. While the two glycoproteins are in constant evolution, the HA/NA balance seems to remain stable in human viruses because an optimal balance is required to maintain good viral fitness. Understanding the evolution of influenza viruses requires an in-depth exploration of the HA/NA balance.
Copyright ? 2016 European Society of Clinical Microbiology and Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
KEYWORDS:
HA/NA balance; Hemagglutinin; Influenza viruses; Neuraminidase
PMID: 27424943 DOI: 10.1016/j.cmi.2016.07.007
[PubMed - as supplied by publisher]