Emerg Infect Dis . Postmortem Stability of SARS-CoV-2 in Mouse Lung Tissue - FluTrackers News and Information

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Emerg Infect Dis . Postmortem Stability of SARS-CoV-2 in Mouse Lung Tissue

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tetano

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Emerg Infect Dis . Postmortem Stability of SARS-CoV-2 in Mouse Lung Tissue

September 26, 2021, 02:25 AM

Emerg Infect Dis

. 2021 Sep 24;27(12).
doi: 10.3201/eid2712.211621. Online ahead of print.
Postmortem Stability of SARS-CoV-2 in Mouse Lung Tissue

Sophie A Valkenburg, Samuel M S Cheng, Asmaa Hachim, Malik Peiris, John Nicholls
PMID: 34559046

DOI: 10.3201/eid2712.211621

Abstract

The infectivity of severe acute respiratory syndrome coronavirus 2 in deceased persons and organisms remains unclear. We studied transgenic K18 hACE2 mice to determine the kinetics of virus infectivity after host death. Five days after death, virus infectivity in the lung declined by >96% and RNA copies declined by 48.2%.

Keywords: 2019 novel coronavirus disease; COVID-19; K18 hACE2 mice; RT-PCR; SARS-CoV-2; TCID50; antigen; coronavirus disease; coronaviruses; experimental infection; infectious virus; mice; postmortem; respiratory infections; severe acute respiratory syndrome coronavirus 2; viruses; zoonoses.

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