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Prog Biophys Mol Biol
. 2020 Oct 30;S0079-6107(20)30110-3.
doi: 10.1016/j.pbiomolbio.2020.10.006. Online ahead of print.
Human coronavirus spike protein-host receptor recognition
Lalitha Guruprasad 1
Affiliations
- PMID: 33137344
- DOI: 10.1016/j.pbiomolbio.2020.10.006
Abstract
A variety of coronaviruses (CoVs) have infected humans and caused mild to severe respiratory diseases that could result in mortality. The human CoVs (HCoVs) belong to the genera of α- and β-CoVs that originate in rodents and bats and are transmitted to humans via zoonotic contacts. The binding of viral spike proteins to the host cell receptors is essential for mediating fusion of viral and host cell membranes to cause infection. In this review, we discuss structural features of HCoV spike proteins and recognition of host proteins and carbohydrate receptors.
Keywords: Amino peptidase N; Angiotensin-converting enzyme 2; Dipeptidyl peptidase 4; HCoV-229E; HCoV-HKU1; HCoV-NL63; HCoV-OC43; Human coronavirus; MERS-CoV; Receptor binding domain; SARS-CoV; SARS-CoV-2; Sialic acid; Spike protein.