Transbound Emerg Dis . Animal Models for SARS-CoV-2 research: A Comprehensive Literature Review

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Transbound Emerg Dis


. 2020 Oct 31.
doi: 10.1111/tbed.13907. Online ahead of print.
Animal Models for SARS-CoV-2 research: A Comprehensive Literature Review


Kabita Pandey ^{1 2} , Arpan Acharya ¹ , Mahesh Mohan ³ , Caroline L Ng ² , Patrick St Reid ² , Siddappa N Byrareddy ^{1 4 5}



Affiliations

• PMID: 33128861
• DOI: 10.1111/tbed.13907

Abstract

Emerging and reemerging viral diseases can create devastating effects on human lives and may also lead to economic crises. The ongoing COVID-19 pandemic due to the novel coronavirus (nCoV), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which originated in Wuhan, China, has caused a global public health emergency. To date, the molecular mechanism of transmission of SARS-CoV-2, its clinical manifestations, and pathogenesis are not completely understood. The global scientific community has intensified its efforts in understanding the biology of SARS-CoV-2 for development of vaccines and therapeutic interventions to prevent the rapid spread of the virus and to control mortality and morbidity associated with COVID-19. To understand the pathophysiology of SARS-CoV-2, appropriate animal models that mimic the biology of human SARS-COV-2 infection are urgently needed. In this review, we outline animal models that have been used to study previous human coronaviruses (HCoVs), including severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV). Importantly, we discuss models that are appropriate for SARS-CoV-2 as well as the advantages and disadvantages of various available methods.

Keywords: Animal Model; Ferret; Hamster; Macaque; Mice; Pathophysiology; SARS-CoV-2.