Future Virol. Renin-angiotensin system in human coronavirus pathogenesis

[tetano]

Future Virol. 2010 Mar;5(2):145-161. doi: 10.2217/fvl.10.4. Epub 2010 Mar 1.
Renin-angiotensin system in human coronavirus pathogenesis.


Wevers BA¹, van der Hoek L².

Author information




Abstract

Although initially considered relatively harmless pathogens, human coronaviruses (HCoVs) are nowadays known to be associated with more severe clinical complications. Still, their precise pathogenic potential is largely unknown, particularly regarding the most recently identified species HCoV-NL63 and HCoV-HKU1. HCoVs need host cell proteins to successively establish infections. Proteases of the renin-angiotensin system serve as receptors needed for entry into target cells; this article describes the current knowledge on the involvement of this system in HCoV pathogenesis.
? 2010 Future Medicine Ltd.



KEYWORDS:

SARS-CoV; aminopeptidase N; angiotensin-converting enzyme 2; human coronavirus 229E; human coronavirus NL63; renin–angiotensin system; virus–host interactions


PMID:32201502PMCID:PMC7079966DOI:10.2217/fvl.10.4