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Enferm Infecc Microbiol Clin (Engl Ed) . Efficacy and effectiveness of influenza vaccination in healthy children. A review of current evidence

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  • Enferm Infecc Microbiol Clin (Engl Ed) . Efficacy and effectiveness of influenza vaccination in healthy children. A review of current evidence


    Enferm Infecc Microbiol Clin (Engl Ed)


    . 2023 Jan 19;S2529-993X(23)00008-4.
    doi: 10.1016/j.eimce.2022.02.016. Online ahead of print.
    Efficacy and effectiveness of influenza vaccination in healthy children. A review of current evidence


    Alejandro Orrico-Sánchez 1 , Ángel Valls-Arévalo 2 , María Garcés-Sánchez 2 , Javier Álvarez Aldeán 3 , Raúl Ortiz de Lejarazu Leonardo 4



    Affiliations

    Abstract

    Influenza is common in healthy children and adolescents and is associated with a high rate of hospitalization in this group, especially for those <5 years. Although the WHO has recommended vaccination in children under 5 years of age since 2012, it is really implemented in few countries today. The aim of this paper was to review the available evidence on the efficacy/effectiveness of influenza vaccination in healthy children <18 years of age through a non-systematic search of studies conducted between 2010 and 2020. Despite the high variability in results due to differences in design, vaccine type and season included in the 41 selected studies, statistically significant studies show efficacy values for the influenza vaccine of between 25.6% and 74.2%, and effectiveness from 26% to 78.8%. Although a systematic review would be necessary to corroborate the evidence, this review suggests that paediatric vaccination is generally an effective measure for preventing influenza in healthy children in line with international organisms' recommendations.

    Keywords: Children; Efectividad; Effectiveness; Efficacy; Eficacia; Gripe; Influenza; Influenza vaccination; Niños; Vacunación antigripal.

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