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Can J Cardiol . Influenza vaccination in congenital heart disease in the pre-COVID19 era: Coverage rate, patient characteristics and outcome

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  • Can J Cardiol . Influenza vaccination in congenital heart disease in the pre-COVID19 era: Coverage rate, patient characteristics and outcome


    Can J Cardiol


    . 2021 May 4;S0828-282X(21)00216-6.
    doi: 10.1016/j.cjca.2021.04.010. Online ahead of print.
    Influenza vaccination in congenital heart disease in the pre-COVID19 era: Coverage rate, patient characteristics and outcome


    Philip Moons 1 , Steffen Fieuws 2 , Corinne Vandermeulen 2 , Fouke Ombelet 3 , Ruben Willems 4 , Eva Goossens 5 , Liesbet Van Bulck 6 , Mich?le de Hosson 7 , Lieven Annemans 4 , Werner Budts 8 , Julie De Backer 7 , St?phane Moniotte 9 , Arianne Marelli 10 , Katya De Groote 11 , BELCODAC consortium



    AffiliationsFree article

    Abstract

    Background: Influenza vaccination is the most commonly recommended immune prevention strategy. However, data on influenza vaccination in patients with congenital heart disease (CHD) is scarce. In this study, our goals were to (i) measure vaccination coverage rates (VCR) for influenza in a large cohort of children, adolescents and adults with CHD, (ii) identity patient characteristics as predictors for vaccination, and (iii) investigate the impact of influenza vaccination on hospitalization.
    Methods: A nationwide cohort study in Belgium included 16,778 patients, representing 134,782 vaccination years, from the BELgian COngenital heart disease Database combining Administrative and Clinical data (BELCODAC). Data over 9 vaccination years (2006-2015) were used, and patients were stratified into five age cohorts: 6 months-4 years; 5-17 years; 18-49 years; 50-64 years; and ?65 years.
    Results: In the respective age cohorts, the VCR was estimated to be 6.6%, 8.0%, 23.9%, 46.6%, and 72.8%. There was a steep increase in VCR as of the age of 40 years. Multivariable logistic regression showed that higher anatomical complexity of CHD, older age, presence of genetic syndromes, and prior cardiac interventions were associated with significantly higher VCRs. Among adults, men had lower and pregnant women had higher VCRs. The association between influenza vaccination and all-cause hospitalization was not significant in this study.
    Conclusion: The influenza VCR in people with CHD is low, especially in children and adolescents. Older patients, particularly those with complex CHD, are well covered. Our findings should inform vaccination promotion strategies in populations with CHD.

    Keywords: counselling; heart defects, congenital; influenza; prevention; vaccination; vaccination coverage rate.

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