Ophthalmic Plast Reconstr Surg. 2019 Nov 21. doi: 10.1097/IOP.0000000000001517. [Epub ahead of print] Acute Unilateral Ptosis and Myositis Following the H1N1 Influenza Vaccine.

Basilious A1, Jivraj I, DeAngelis D.
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1 Department of Ophthalmology and Vision Sciences, University of Toronto, Toronto, Ontario, Canada.


The authors present a rare case of sudden onset unilateral complete ptosis occurring hours after administration of the H1N1 influenza vaccine. A complete workup for autoimmune and neurological disease was negative. MRI of the orbits demonstrated unilateral orbital myositis involving the left superior rectus/levator complex, superior oblique, and medial rectus muscles. Ptosis resolved spontaneously over 2 months without intervention. An autoimmune mechanism may explain rare cases of orbital myositis following administration of the H1N1 influenza vaccination.

PMID: 31770175 DOI: 10.1097/IOP.0000000000001517