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Immunogenicity of influenza vaccination in patients with cancer receiving immune checkpoint inhibitor

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  • Immunogenicity of influenza vaccination in patients with cancer receiving immune checkpoint inhibitor


    Clin Infect Dis. 2019 Nov 4. pii: ciz1092. doi: 10.1093/cid/ciz1092. [Epub ahead of print] Immunogenicity of influenza vaccination in patients with cancer receiving immune checkpoint inhibitor.

    Keam B1,2, Kang CK1, Jun KI1, Moon SM3, Suh KJ3, Lee DW1,2, Ock CY1,2, Kim M1,2, Choi Y4, Lim Y1,2, Lee KH1,2, Kim SH3, Kim TM1,2, Kim TY1,2, Oh DY1,2, Kim DW1,2, Im SA1,2, Lee JS3, Kim ES3, Kim HB3, Kim NJ1, Kim YJ3, Park WB1, Oh MD1.
    Author information

    1 Department of Internal Medicine, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea. 2 Cancer Research Institute, Seoul National University College of Medicine, Seoul, Republic of Korea. 3 Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Republic of Korea. 4 Medical Research Collaborating Center, Seoul National University Hospital, Seoul, Republic of Korea.

    Abstract

    Among prospectively enrolled adult patients with cancer receiving immune checkpoint inhibitors (ICIs, n=46) or cytotoxic agents (n=90), seroprotection and seroconversion rates after seasonal quadrivalent influenza vaccinations were higher with ICI than with cytotoxic chemotherapy. These results supports administration of annual influenza vaccinations for patients with cancer that receive ICIs.
    The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.


    KEYWORDS:

    Influenza; immune checkpoint inhibitor; immune-related adverse event; immunogenicity; vaccination

    PMID: 31680143 DOI: 10.1093/cid/ciz1092


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